It activates endogenous T cells by linking the CD3 antigen
in the T cell receptor complex with the CD19 surface antigen on benign and malignant B cells.
Significant suppressive effect of high doses of BWD-1 (75 [micro]g/[cm.sub.2]) on proliferative activity of T-lymphocytes activated through the T-cell receptor was shown in cultures stimulated with CD3 antigen
. Less suppressive effect of high dose of BWD-1 was observed for PWM antigen.
Other than CD3 antigen
, TCAs are infrequently investigated in routine HL cases.
Table 4: Technological characteristics of Mab products in China Non-proprietary Technology source Technological name characteristics Mouse anti-human Self-development A pioneer in the CD3 antigen
of T Chinese Mab market; lymphocytes for direct effect on T injection cells that play a major role in organ transplant rejection.
Neoplastic cells of the penguin as well as of the pelican were immunoreactive to CD3 antigen, suggesting the lymphomas were of T-cell origin.
T-cell lymphoma, CD3 antigen, avian, melanoma, penguin, Spheniscus humboldti, pelican, Pelecanus rufescens
The T-cell origin was proven immunohistochemically by positive reaction to CD3 antigen. To our knowledge, this is the first report of a disseminated T-cell lymphoma in both species.
The CD3 antigen
consists of at least 5 invariable/constant membrane proteins and is associated with 2 variable immunoglobulin-like glycoproteins, the T-cell receptor [alpha] and [beta] chains.
The CD3 antigen
, which is part of the protein complex associated with the TCR (Fig.
Additionally, newly-reported analyses showed increased CD8+ T cell density at the tumor interface, with the total density of CD8+ cells inside the tumor boundary area increased four-fold compared with baseline; increased numbers of cells expressing CD3 antigens
, a pan T-cell marker, within tumor borders, and decreased expression of VISTA, a checkpoint molecule that inhibits T-cell activation and proliferation; increases in multiple chemoattractant factors in serum, consistent with increased trafficking of immune cells post CXCR4 inhibition.