CD3


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CD3

a type I transmembrane protein found on T cells that forms the signal transduction unit for the T cell; expressed in patients with T-cell lymphomas.

CD3

T3 A complex of 5 invariable polypeptide chains, which are part of a larger complex that includes the T cell receptor; CD3 is 'pan-T' cell antigen–ie, present on most mature T cells–60-85% of peripheral T cells, 20-85% of thymocytes. See Pan-T cell markers.

CD2

cluster of differentiation or cell differentiation glycoproteins.

CD antigen
a group of cell surface molecules which act as markers on T lymphocytes.
CD3
found on T helper (Th) and T cytotoxic (Tc) lymphocytes; associated with signal transduction.
CD4
found on T helper lymphocytes; an adhesion molecule that binds to class II MHC molecules.
CD8
found on T cytotoxic and variably on NK lymphocytes; an adhesion molecule that binds to class I MHC molecules.
References in periodicals archive ?
XmAb15426 (intermediate CD3 affinity) testing in primates showed more sustained depletion of CD38+ cells than XmAb13551 (7 days vs.
9 for 30 minutes at 96[degrees]C), whereas CD3 detection required protease predigestion (0.
The paraffin-embedded slides were then stained for the expression of CD3 in the Pathology Core at the Hospital of the University of Pennsylvania.
This is true for CD1 fall season, CD2 summer and winter seasons, and CD3 summer and winter seasons.
When leukocytes were stained with several fluorescein-labeled antibodies, CD3, CD8, CD45, and CD45RA, the spectra of the stained cells shift further to the red with respect to those of the antibodies (Fig.
With the easy colorability afforded by the material, CD3 manufactures the case in a variety of colors, including blue, orange, green, and yellow.
The preclinical results showed Emergent's SCORPION(TM) (multi-specific protein therapeutic) molecules targeting prostate-specific membrane antigen (PSMA) and CD3 redirected T-cell cytotoxicity against PSMA-positive tumor cells and show potential for further investigation as possible therapeutic agents for treating castrate-resistant prostate cancer.
This pre-clinical dataset validates antibody-based CD3+ T-cell imaging, and sets the stage for development of a CD3 targeted antibody fragment imaging agent.
Among the 600 new mouse reagents are antibodies for CD3, CD4, CD8 and CD45.
All white blood cells have CD45 receptors, but only subsets have other receptors such as CD20, CD3, and CD8.
As recently reported (2), we developed an immunoassay that quantifies CD3, a component of the T-cell receptor complex (3), to provide an alternative or complementary method to T-cell receptor excision circles testing.
The next Fusion will be based on Mondeo's newer EUCD platform rather than the current Fusion's CD3 platform.