CD27


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CD27

a type I transmembrane protein present on mature T cells, medullary thymocytes, and some B cells that is a ligand for CD70 and serves as a member of the nerve growth factor family; expressed in chronic lymphocytic leukemia.
References in periodicals archive ?
CD27 expression in the human splenic marginal zone: the infant marginal zone is populated by naive B cells.
Data from the Phase 1/2 study of Celldex's varlilumab, a CD27 targeting investigational immune-activating antibody, and Bristol-Myers Squibb's (BMY) Opdivo, or nivolumab, an anti-PD1 immunotherapy, for patients with ovarian cancer and colorectal cancer, were presented.
Among the better-known checkpoint inhibitors are PD1, CTLA-4, PDL, KIR, IDO1, 4-1BB, 0X40, LAG3, B7-H3, CD27, CD70, CD28 and CD30.
Duodenal-type FL shows expression that differs from that of GI-FL with regard to CD27 and activation-induced cytidine deaminase (AID).
We then chose to further study a memory phenotype definition based on CD27 and CD45RO.
Some studies showed an increased expression of the activation markers CD27 and CD38 in mature B cell compartments [5, 58, 59].
Noteworthy, 38 genes prevalently related to B cell activity (i.e., IL2RG, IL6R, KLF12, and CD27) were also modulated, indicating an important role for this cell subset in NCGS, 20 genes involved in T cell activation were upregulated in NCGS samples (i.e., CD28, CD3E, CD3G, and CTLA-4).
HLH-related genes (including AP3B1, FASLG, PRF1, TNFRSF1A, BIRC4, ITK, RAB27A, UNC13D, CASP10, ITPKC, SH2D1A, CD27, LYST, STX11, FAS, MAGT1 and STXBP2) were detected with high-throughput sequencing.
In contrast, the noncanonical NF-[kappa]B-activating pathway is activated by B-cell activating factor (BAFF) [35], lymphotoxin [beta] (LT[beta]) [36], CD40 ligand [37], CD27 ligand [38], human T-cell leukemia virus (HTLV) [39], and Epstein-Barr virus (EBV) [40] and it relies on IKK[alpha] and causes activation of NF-[kappa]B2/RelB complexes by inducing the proteolytic processing of the NF-[kappa]B2/p100 precursor.