CD26

CD26

a type II transmembrane protein present on mature T cells, some B cells, apical membranes of epithelial and endothelial cells, kidney, intestinal brush borders, and liver bile canaliculi; combines with collagen and associates with adenosine deaminase.

DPP4

A gene on chromosome 2q24.3 that encodes dipeptidyl-peptidase 4, a ubiquitous, membrane-bound enzyme with roles in nutrition, metabolism, the endocrine system, immune regulation (for instance, it is essential for T-cell receptor (TCR)-mediated T-cell activation), bone marrow mobilisation, apoptosis, cell adhesion and tumourigenesis.
References in periodicals archive ?
Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26.
1993) reported that direct relationship between the CD26 and ADA asserted to these interactions may provide a clue for pathophysiology of severe combined immune deficiency related to ADA deficiency.
Known as LCA60, it binds to the virus when it encounters it, preventing the virus from binding to CD26 receptor cells.
La enzima se localiza tanto en citoplasma donde mantiene su actividad hidrolasa, como en la superficie de diversas celulas; por lo que es considerada una ecto-enzima y mantiene su funcion incluso despues de unirse a la glicoproteina CD26, la cual involucra la desaminacion de la adenosina extracelular cuando se encuentra en elevados niveles que son toxicos para los linfocitos (3).
Estas caracteristicas serian la base para atacar, por ejemplo, marcadores tumorales en cancer que clasicamente no responde a quimioterapia usando marcadores descubiertos recientemente como el CD44 y CD26 en cancer gastrico obtenidos de muestras quirurgicas en humanos [15].
Often, these peripheral blood cells show loss of T-cell antigens, most commonly CD7 and CD26 (23) (demonstrable by flow cytometry), but may also show loss of CD2, CD3, CD4, and CD5.
AMD3100 and CD26 modulate mobilization, engraftment, and survival of hematopoietic stem and progenitor cells mediated by the SDF-1/CXCL12-CXCR4 axis.
Following therapy with methoxsalen and UVA light, inflammatory blebs released from apoptotic cells demonstrated an increase in CD5, a surface marker thought to contribute to immunosupression, thereby conferring protection against autoimmunity, and a decrease in the exposure of CD28 and CD26 (16).
Circulating cytokines and soluble CD23, CD26 and CD30 in ANCAassociated vasculitides.
Fusin arrives center stage almost 3 years after a French research group announced that a molecule called CD26 was the elusive HIV fusion cofactor.
Engraftment preclinical and clinical enhancements such as use of prostaglandin E2, inhibition of cell surface protein CD26, expansion of shortterm
La enzima se localiza tanto en citoplasma donde mantiene su actividad hidrolasa, como en la superficie de diversas celulas; por lo que es considerada una ecto-enzima (8) y mantiene su funcion incluso despues de unirse a la glicoproteina CD26, catalizando la desaminacion de la adenosina extracelular cuando se encuentra en elevados niveles que son toxicos para los linfocitos (9, 10).