IL2RA

(redirected from CD25 antigen)

IL2RA

A gene on chromosome 10p15-p14 that encodes the alpha subunit of interleukin-2 (IL-2) receptor, which forms either a heterodimer with the beta subunit, resulting in a receptor with intermediate-affinity for IL-2, or a heterotrimer with beta and gamma subunits, resulting in a high-affinity IL-2 receptor.

Molecular pathology
Genetic variations in IL2RA are associated with susceptibility to diabetes mellitus insulin-dependent type 10.
References in periodicals archive ?
In our study we reported a simultaneous multiparametric (mp) analysis of cell proliferation, measuring DNA synthesis by BrdU (a thymidine analogue) incorporation and expression of CD25 antigen as T cell activation marker.24
A likely explanation is that CD25 antigen is a late activation marker and is expressed by T cells somewhat later in response to these stimuli.29
It has been shown that unlike other nonregulatory CD4+ cell populations, Treg cells in addition to the CD4 and CD25 antigens do not carry the CD127 antigen [27].