CD25

CD25

a type I transmembrane protein present on activated T cells, activated B cells, some thymocytes, myeloid precursors, and oligodendrocytes that associates with CD122 to form a heterodimer that can act as a high-affinity receptor for IL-2; expressed in most B-cell neoplasms, some acute nonlymphocytic leukemias, and neuroblastomas.

CD25

A 55-kD monomeric glycoprotein low-affinity receptor for IL-2–IL-2R alpha. With p75 beta chain—CD122 antigen, IL-2Rbeta—CD25 forms a high affinity IL-2R complex.

Normal expression
CD25 is expressed on activated T and B cells in the germinal centre, mantle zone, on activated macrophages and thymic medulla cells; it is absent from thymocytes and resting T and B cells.

Abnormal expression
Hairy cell leukaemia and Hodgkin lymphoma, and may be expressed on T and B cell NHLs, and HTLV I/II-associated T cell leukaemias.
References in periodicals archive ?
Effector cells: CD62L, CD44, CD45RA, CD45RO, CD27, CD28, CD69, Costimulatory molecules CTLA4, ICOS, FAS, PD-1, CD25, CD127, - chemokine receptors CCR7, CCR4, CXCR3, CXCR4, CXCR5, CCR6, CX3CR1, - apoptosis / living dead differentiation annexin, live dye z.
Current strategies to deplete Tregs by using monoclonal antibodies to target cell surface proteins such as CD25 and GITR have demonstrated mixed results, perhaps because CD25 and GITR are also expressed in CD4 and CD8 effector T-cells, resulting in the mAbs killing both the Tregs and the effector T-cells.
We used the combination of the surface markers CD4, CD25, and CD127 to identify Tregs.
Splenocytes were stained with anti-mouse CD4 mAb and anti-mouse CD25 mAb (7D4) after incubation with the 2.4G2 antibody.
T cell proliferative response was assessed against bovine collagen II by measuring incorporation of bromodeoxyuridine into deoxyribonucleic acid of proliferating cells and by expression of CD25 on proliferating cells as percentage of CD3+/bromodeoxyuridine+ and CD3+/CD25+ T-cells, respectively.
Decidual and peripheral blood CD4 + CD25 + regulatory T cells in early pregnancy subjects and spontaneous abortion cases.
Her soluble CD25 eventually returned and was elevated at 9420 pg/mL.
Though Tregs in mice express CD25 constitutively, in humans only those with CD25 show suppressive function.10 Leprosy reactions in contrast showed a decrease in Treg cells which paralleled the increase in Th17 population.11 Moreover, there was downregulation of intracellular TGF-[beta].11,12 Most reports showed a reduction in Treg cells in patients with ENL reactions compared with non-reaction lepromatous leprosy counterparts.11,12
Regulatory T cells come in many forms with the most well-understood being those that express the markers CD4, CD25, and FOXP3.
Tusk Therapeutics, Cancer Research UK (via its Commercial Partnerships Team) and UCL announced in 2017, an exclusive licensing and collaboration deal to develop and commercialise antibody-based therapeutics against CD25.
An immunophenotypic analysis of lymphocytes in peripheral blood expressing CD4, CD25, CD127, and Foxp3 antigens could be performed in 18 patients before, 2 weeks, and 2 months after IFN-[alpha] therapy at the time of the initial evaluation of the efficacy of IFN-[alpha] therapy.
Although different T cell types with regulatory functions have been identified, the most physiologically relevant Treg population is characterized as [CD4.sup.+] T lymphocytes that constitutively express the IL-2 receptor a-chain, CD25, and the transcription factor Foxp3, comprising approximately 10% of the [CD4.sup.+] T cell compartment [5].