CD25

CD25

a type I transmembrane protein present on activated T cells, activated B cells, some thymocytes, myeloid precursors, and oligodendrocytes that associates with CD122 to form a heterodimer that can act as a high-affinity receptor for IL-2; expressed in most B-cell neoplasms, some acute nonlymphocytic leukemias, and neuroblastomas.

CD25

A 55-kD monomeric glycoprotein low-affinity receptor for IL-2–IL-2R alpha. With p75 beta chain—CD122 antigen, IL-2Rbeta—CD25 forms a high affinity IL-2R complex.

Normal expression
CD25 is expressed on activated T and B cells in the germinal centre, mantle zone, on activated macrophages and thymic medulla cells; it is absent from thymocytes and resting T and B cells.

Abnormal expression
Hairy cell leukaemia and Hodgkin lymphoma, and may be expressed on T and B cell NHLs, and HTLV I/II-associated T cell leukaemias.
References in classic literature ?
The rains had made channels of the wheel-ruts and washed them so deeply that the sod had never healed over them.
Nor was the Doctor happier in his selection, when he told the old, ever new and curious story of the waning of a woman's love, seeking strange, new channels, only to return to its legitimate source after days of fierce unrest.
Notwithstanding the Hurons were necessarily ignorant of the little channels among the eddies and rapids of the stream, they knew the common signs of such a navigation too well to commit any material blunder.
I mean," he said hastily, "that you have the same opportunity to direct the lives of these young men into more regular, disciplined channels that I have to regulate and correct their foolish waste of industry and material here.
All down her sides, this spectral appearance was traced with long channels of reddened rust, while all her spars and her rigging were like the thick branches of trees furred over with hoar-frost.
As, blind and deaf, the whale plunged forward, as if by sheer power of speed to rid himself of the iron leech that had fastened to him; as we thus tore a white gash in the sea, on all sides menaced as we flew, by the crazed creatures to and fro rushing about us; our beset boat was like a ship mobbed by ice-isles in a tempest, and striving to steer through their complicated channels and straits, knowing not at what moment it may be locked in and crushed.
They own not merely the labor of society, they have bought the governments; and everywhere they use their raped and stolen power to intrench themselves in their privileges, to dig wider and deeper the channels through which the river of profits flows to them
Lore (two syllables) was a water nymph who used to sit on a high rock called the Ley or Lei (pronounced like our word LIE) in the Rhine, and lure boatmen to destruction in a furious rapid which marred the channel at that spot.
His audience, accordingly, gave him up in despair; and the kitchen small-talk flowed back into its ordinary channels, until the clock struck eight and startled the assembled servants into separating for their morning's work.
The house fronts looked black enough, and the windows blacker, contrasting with the smooth white sheet of snow upon the roofs, and with the dirtier snow upon the ground; which last deposit had been ploughed up in deep furrows by the heavy wheels of carts and waggons; furrows that crossed and recrossed each other hundreds of times where the great streets branched off; and made intricate channels, hard to trace in the thick yellow mud and icy water.
A less truthful man than he might have been tempted into the subsequent creation of a vision in the form of resurgent memory; a less sane man might have believed in such a creation; but Silas was both sane and honest, though, as with many honest and fervent men, culture had not defined any channels for his sense of mystery, and so it spread itself over the proper pathway of inquiry and knowledge.
The Golden Fortune was curiously situated, perched at the extreme sea-end of a little horse-shoe bay hollowed out between two headlands, the points of which approached each other so closely that the river Sly had but a few yards of rocky channel through which to pour itself into the sea.