CD246 | definition of CD246 by Medical dictionary
ALK (redirected from CD246)
ALK Abbreviation for:
anaplastic lymphoma kinase, see there
A gene on 2p23 that encodes an orphan receptor with tyrosine kinase activity belonging to the insulin receptor superfamily, which plays an important role in brain development.
ALK is amplified, mutated and rearranged in various cancers, including anaplastic large cell lymphomas, neuroblastoma and non-small cell lung cancer. The most common genetic alterations seen in ALK malfunction are chromosomal rearrangements resulting in multiple fusion genes, including ALK/EML4, ALK/RANBP2 and ALK/ATIC (all on chromosome 2); ALK/TFG (on chromosome 3); ALK/NPM1 and ALK/SQSTM1 (both on chromosome 5); ALK/KIF5B (on chromosome 10); ALK/CLTC (on chromosome 17); ALK/TPM4 (on chromosome 19); and ALK/MSN (on X chromosome).
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References in periodicals archive
(157) The ALK1 antibody (mouse monoclonal anti-human CD246
, clone ALK1) typically used to diagnose anaplastic large cell lymphoma failed to identify a significant number of the ALK rearranged NSCLCs using standard techniques.
anti-ALK protein mouse monoclonal antibody (mAB) and anti-nucleophosmin mouse mAB, were from Dako Cytomation (Glostrup, Denmark), PDGF-R[beta] rabbit mAB and caspase 3 polyclonal antibody (pAB), histone H3 rabbit mAb and phospho-histone H3 rabbit pAB from Cell Signaling (Cambridge, UK).
However, IHC studies using the anti-ALK1 antibody typically used for anaplastic large celll ymphoma (mousemonoclonalanti-human CD246
, clone ALK1) have been disappointing, likely due to the low expression level of the fusion protein in ALKrearranged lung adenocarcinomas in comparison to anaplastic large cell lymphoma.
Immunohistochemical staining for ALK (CD246
) was performed with the mouse monoclonal antibody (clone ALK1) from Dako (Carpinteria, Carpinteria).