MUC1

(redirected from CD227)

MUC1

A 265- to 400-kD transmembrane glycoprotein encoded by MUC1 on chromosome 1q21, which is found in milk-fat globule membranes.

Normal expression
Normal epithelia and perineurial cells, choroid plexus, arachnoid granulation, epithelioid histiocytes.

Abnormal expression
Neoplastic epithelia, meningiomas, mesotheliomas, mesenchymal tumours, some lymphomas, anaplastic large cell lymphomas.
References in periodicals archive ?
Incubation with mouse anti human monoclonal CD227 antibody (mucin 1) (clone VU-3C6, AbDSerotec, 1:200 dilution), mouse anti human monoclonal mucin 4 antibody (clone 5B12, AbDSerotec; 1:1000 dilution) and mouse anti human monoclonal mucin 5AC antibody (clone 1-13M1, AbDSerotec, 1:200 dilution) for properly 30, 10 and 30 minutes in room temperature.
Nine antigens (CD44, CD49e, CD71, CD221, CD227, EGFR, EpCAM, Her2, and Her3) are breast-tumor related and expressed by at least one of the included cell lines (19).