IGF1R

(redirected from CD221)

IGF1R

A gene on chromosome 15q26.3 that encodes a tyrosine kinase receptor with a high binding affinity for insulin-like growth factor, which plays a key role in transformation events in cell growth and survival.

Molecular pathology
IGF1R is highly overexpressed in cancer where it has anti-apoptotic activity, enhancing malignant cell survival.
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Nine antigens (CD44, CD49e, CD71, CD221, CD227, EGFR, EpCAM, Her2, and Her3) are breast-tumor related and expressed by at least one of the included cell lines (19).
6) and parental cell exposure reported elsewhere (19, 37-39), albeit higher exposure was expected for CD221 and Her3 (39, 40).
(82) Among a wide range of markers, including CD138, CD81, CD200, CD221, CD45, CD38, CD28, CD19, CD27, CD117, CD38, CD33, CD20, CD56, CD10, Ig[kappa] and Ig[lambda] light chains, absence of the expression of CD19 and/or CD27 resulted in optimal concordance with histology and reproducible detection of MRD based on a new statistical diagnostic model.