CD209L | definition of CD209L by Medical dictionary
CLEC4M (redirected from CD209L)
CLEC4M A gene on chromosome 19p13 that encodes a pathogen-recognition receptor expressed on the surface of immature dendritic cells which is involved in initiating a primary immune response. The receptors are thought to recognise high-mannose N-linked oligosaccharides present on the surface of pathogens (such as HIV-1, HIV-2 and SIV gp120, among others) in a calcium-dependent fashion. Once bound, the receptor mediates endocytosis of the pathogens, which are subsequently degraded in lysosomal compartments. The receptor then returns to the cell membrane surface, and the pathogen-derived antigens are presented to resting T cells via MHC class-II proteins to initiate the adaptive immune response.
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References in periodicals archive
Two micrometre sections were cut onto poly-L-lysine coated slides and stained with DC-SIGN (purified mouse antihuman CD209 antibody, dilution 1:40, BD Biosciences, US) and DC-SIGNRs (monoclonal antihuman CD209L
antibody, dilution 1:40, R&D systems, US) using the Envision kit.
L-SIGN or DC-SIGNR (also known as CD299, CD209L
, and Clec4M) is a type-II transmembrane C-type lectin receptor homologous to DC-SIGN (77% amino acid sequence homology), highly expressed on liver sinusoidal cells, endothelial vascular cells, and in the lymph nodes, but not on DCs, in contrast to DC-SIGN (Table 1 and Figure 1).
(L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus.