CD209

CD209

A gene on chromosome 19p13 that encodes a pathogen-recognition receptor expressed on the surface of immature dendritic cells which is involved in initiating a primary immune response. These receptors are thought to recognise high mannose N-linked oligosaccharides present on the surface of pathogens (such as HIV-1, HIV-2 and SIV gp120, amongst others) in a calcium-dependent fashion. Once bound, the receptor mediates endocytosis of the pathogens, which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface, while the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response.
References in periodicals archive ?
Interleukin-4 regulates the expression of CD209 and subsequent uptake of Mycobacterium leprae by Schwann cells in human leprosy.
CD209 promoter -336 A/G (rs4804803) polymorphism is associated with susceptibility to pulmonary tuberculosis in Zahedan: southeast Iran.
Varios componentes de Schistosoma mansoni actuan directamente sobre las CD, tales como algunos glicanos que son reconocidos a traves de CD209 y promueven la polarizacion hacia Th2 (45).
On the other hand moDCs were negative for CD14 and positive for CD206 and CD209.
Two micrometre sections were cut onto poly-L-lysine coated slides and stained with DC-SIGN (purified mouse antihuman CD209 antibody, dilution 1:40, BD Biosciences, US) and DC-SIGNRs (monoclonal antihuman CD209L antibody, dilution 1:40, R&D systems, US) using the Envision kit.
DCs, however, do not utilize CD14, but instead require CD209 (DC-SIGN).
Epigenotype switching at the CD14 and CD209 genes during differentiation of human monocytes to dendritic cells.
Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis.