CD209

CD209

A gene on chromosome 19p13 that encodes a pathogen-recognition receptor expressed on the surface of immature dendritic cells which is involved in initiating a primary immune response. These receptors are thought to recognise high mannose N-linked oligosaccharides present on the surface of pathogens (such as HIV-1, HIV-2 and SIV gp120, amongst others) in a calcium-dependent fashion. Once bound, the receptor mediates endocytosis of the pathogens, which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface, while the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response.
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Tenders are invited for Supply of Chemicals: Cd209 B (Ertr9): Antibod Y, Sumo -1 Antibod Y, Beta Actin, Cd209 B Sirna
On the contrary, M2 macrophages have been demonstrated to express high levels of dectin-1, DCSIGN (CD209), mannose receptor (CD206), scavenger receptor A, scavenger receptor B-1, CD163, CCR2, CXCR1, and CXCR2 [23] and to produce a large amount of IL-10, YM1, macrophage and granulocyte inducer-form 1 (MgI1), and arginase-1, highlighting their relevance during tissue remodelling and repair [24].
In the former study, macrophage expression of CD163 and CD209 and their intracellular expression and extracellular secretion of transforming growth factor-beta 1 (TGF-[beta]1) and interleukin-10 (IL-10) was increased compared to macrophages treated with [ESC.sub.endo] from healthy controls [53].
Kapp et al., "Unique appearance of proliferating antigen-presenting cells expressing DC-SIGN (CD209) in the decidua of early human pregnancy," American Journal of Pathology, vol.
Three major attachment factors for Flavivirus are heparin sulfates, dendritic cell-specific ICAM-3-grabbing non-integrin 1 (DC-SIGN, CD209 antigen), and DC-SIGNR (CLEC4M), which interact with N-linked glycans of the viral E glycoprotein.
Interleukin-4 regulates the expression of CD209 and subsequent uptake of Mycobacterium leprae by Schwann cells in human leprosy.
CD209 promoter -336 A/G (rs4804803) polymorphism is associated with susceptibility to pulmonary tuberculosis in Zahedan: southeast Iran.
Varios componentes de Schistosoma mansoni actuan directamente sobre las CD, tales como algunos glicanos que son reconocidos a traves de CD209 y promueven la polarizacion hacia Th2 (45).
DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells.
Two micrometre sections were cut onto poly-L-lysine coated slides and stained with DC-SIGN (purified mouse antihuman CD209 antibody, dilution 1:40, BD Biosciences, US) and DC-SIGNRs (monoclonal antihuman CD209L antibody, dilution 1:40, R&D systems, US) using the Envision kit.
On the other hand, K5 down regulates MHC I HLA-A, adhesion molecules like ICAM-1, PECAM, ALCAM, and VE-cadherin, ligands for natural killer (NK) T-cells (CD1d), ligands for NK cells (MICA, MICB, AICL), IFN[gamma]R1, cellular restriction factors (BST-2, also known as tetherin), the viral receptor proteins DC-SIGN (CD209) and DC-SIGNR (CD209R), the plasma membrane t-SNARE syntaxin-4 (SX4), a member of the TGF[beta] family, and the ligand B7-2, which is necessary for activation of T-cells by antigen-presenting cells (APCs) [1,10,11,14-22].
DCs, however, do not utilize CD14, but instead require CD209 (DC-SIGN).