CD207

A gene on chromosome 2p13 that encodes a calcium-dependent mannose-binding lectin, expressed only by Langerhans cells of the pancreas, which induces Birbeck granule formation. It binds to sulphated and mannosylated glycans, keratan sulfate and beta-glucans, facilitates uptake of antigens, and is involved in routing and processing of antigens for presentation to T cells. CD207 is a major receptor on Langerhans cells for Candida spp and Malassezia furfur; it protects against HIV-1 infection.

References in periodicals archive ?

Histopathology of LCH shows a granulomatous infiltrate that is epidermotropic, and the presence of positive CD1a or CD207 staining confirms the diagnosis, he said.

Don't miss these dermatology diagnoses in children

Histopathology of LCH shows a granulomatous infiltrate that is epidermotropic, and the presence of positive CDla or CD207 staining confirms the diagnosis, he said.

Don't miss these dermatology diagnoses in children

3 that spanned about 735 kb and included 10 genes: CD207 (CD207 molecule, langerin), VAX2 (ventral anterior homeobox 2), ATP6V1B1 (ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunitB1), ANKRD53 (ankyrin repeat domain 53), TEX261 (testis expressed 261), NAGK (N-acetylglucosamine kinase), MCEE (methylmalonyl CoA epimerase), MPHOSPH10 [M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)], PAIP2B [poly(A) binding protein interacting protein 2B], and ZNF638 (zinc finger protein 638), as well as the first 20 exons of DYSF [dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)], which causes LGMD2B (33).

Motor chip: a comparative genomic hybridization microarray for copy-number mutations in 245 neuromuscular disorders