MRC1

(redirected from CD206)

MRC1

A gene on chromosome 10p12.33 that encodes a C-type lectin domain protein which is a type-I membrane receptor. MRC1 mediates the endocytosis of glycoproteins by macrophages by binding to high-mannose structures on the surface of viruses, bacteria and fungi, so as to facilitate engulfment by phagocytes.
References in periodicals archive ?
Navidea's Manocept platform is predicated on the ability to specifically target the CD206 mannose receptor expressed on activated macrophages.
CD14 (555-397, BD Bioscience, Heidelberg, Germany), CD68 (11-0689-42, eBioscience, Frankfurt am Main, Germany), CD163 (12-1639-42, eBioscience), and CD206 (12-2069-42, eBioscience) were used as positive markers for macrophages.
In contrast, M2 microglia have an antiinflammatory phenotype, and express different molecules such as IL-4, arginase 1, Ym1, CD163, CD206, and IL10.
In the current study we have investigated the possibility of CD89 and CD206 targeting on monocytes and moDCs to enhance processing of HLA class I alloantigen and antigen presentation to CD4 T-cells, as a tool to facilitate the detection and monitoring of indirect T-cell alloreactivity.
Alexa Fluor 488-labeled anti-mouse CD206 antibodies, PE-labeled anti-mouse F4/80 antibodies, and APC-labeled anti-mouse CD11c antibodies were added to the SVF, and the resultant mixture was incubated under the same conditions.
Entre estas moleculas estan: 1: Lectina de superficie, tipo II, conocida como langerina CD206, es producida cuando la celula es inmadura, actua como receptor endosomico de manosa, se acumula formando los granulos de Birbeck, y al fijar el antigeno permite que se inicie una via no clasica en el procesamiento de estos.
El receptor de la manosa, llamado CD206, que facilita la fagocitosis de los microorganismos, se expresa principalmente en celulas de la linea mieloide, especialmente macrofagos maduros donde el mayor ligando micobacterial es el lipoaraminomanosa (uno de los componentes de la capsula bacilar) actuando como inmunomoduladora de la respuesta inmune (8).
NADPH oxidase of human dendritic cells: role in Candida albicans killing and regulation by interferons, dectin-1 and CD206.
Exploitation Targeting Of The CD206 Receptor In Lymph Node-Resident Reticuloendothelial Cells With A Novel Synthetic 99mTc-ligand (Tilmanocept) Significantly Enhances Localization In Contrast To 99mTc-Colloid: A New Meta-analysis
Activation of the M2 phenotype by IL-4, IL-10, and/or IL-13 induces surface-receptor expression of several distinct antigens, such as arginase, heparin-binding lectin Ym-1, CD206, and CD36.
Enhanced Sentinel Node Evaluation in Breast Cancer, Melanoma, and Head/Neck Squamous Cell Carcinoma Via CD206 Receptor Targeting With Tc99m-tilmanocept
Tc99m Tilmanocept, A CD206 ILM Agent, Has >24 Hour Stability in Nodes and Concordance with Imaging in Breast Cancer