Ly75

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Ly75

A gene on chromosome 2q24 that encodes a C-type lectin-domain protein which acts as an endocytic receptor, directing captured antigens from the extracellular space to a specialised antigen-processing compartment. Ly75 also downregulates B-cell proliferation.
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References in periodicals archive ?
The study showed that CD205, a transmembrane glycoprotein, is robustly expressed in a variety of solid malignancies, such as pancreatic and bladder tumors, as well as triple negative breast cancer (TNBC).
CD205, a target antigen for a novel antibody drug conjugate (ADC): Evaluation of antigen expression on non-Hodgkin lymphoma (NHL).
The product is an antibody drug conjugate that includes a fully human antibody targeting CD205, coupled to the DM4 toxin from Immunogen.
Abbreviations, CD numeration, and alternate names: DEC-205 (CD205), B220 (CD45R), PDCA-1 (plasmacytoid DC Ag-1; CD317; Bst2), Siglec H (Sialic acid-binding immunoglobulin-like lectin H), Langerin (CD207), CD141 (BDCA-3), CD1c (BDCA-1), and CD303 (BDCA-2).
DEC-205 (CD205 or lymphocyte antigen Ly 75) is a type-I integral membrane protein homologous to the macrophage MR family of C-type lectins, which binds carbohydrates and mediates endocytosis (Figure 1) [173].
Ordenandoas decrescentemente da mais plantada para as menos plantadas, tem-se a seguinte relacao: "CD206", "CD215", "Embrapa48", "BRS184", "M-SOY5826", "CD205", "BRS214", "Spring NK8350", "BRS133".
El rastreo genetico le hace pertener al subgrupo VI de lectinas, donde comparte familiaridad con miembros como la lectina DEC205 (en nomenclatura de antigenos hemato-inmunes, CD205) y MCR1(del ingles macrophage mannose receptor 1), presente en celulas presentadoras de antigenos (APC) del tipo celulas dendriticas.
Ademas, las DCM tambien expresan receptores tipo lectina, como DC-SIGN (CD209), DEC205 (CD205), los receptores de manosa (CD206) y la langerina (CD207), moleculas implicadas en la union e internalizacion del VIH-1 hacia compartimentos endosomales (11).
Un total de 39 registros correspondientes a becerros y becerras fueron analizados por un modelo que incluyo los efectos fijos del abuelo materno (AMT; 8 toros), epoca de nacimiento del becerro (ENT; sequia y lluvias) y regresion del ano de nacimiento de la madre (ANV; 92, 93, 94 y 95) sobre las variables de crecimiento de los becerros: peso al nacer (PN), peso al destete (PD), ganancia diaria de peso (GDP), peso ajustado a 205 dias (P205-d), ganancia diaria de peso a 205 dias (GDP205-d) y cocientes de peso por sexo a 205 dias (CD205).
The following combination of antibodies wasusedtocharacterizethe phenotypeofMDDCs: (a) MHCIIFITC (mouse IgG2a k), SLAMF1 PE (mouse IgG1 k), CD11c PerCP-eFluor 710 (mouse IgG1 k), and B7/H1 APC (mouse IgG1 k); (b) CD83 FITC, CD80 PE, CD11c PerCP-eFluor 710 (mouse IgG1 k), and CD86 APC (mouse IgG1 k); (c) CD205 FITC (mouse IgG2b k), CD40 PE (mouse IgG1 k), CD11c PerCP-eFluor 710 (mouse IgG1 k), and ILT3 APC (mouse IgG1 k).
The study showed that CD205, a trans membrane glycoprotein, is robustly expressed in a variety of solid malignancies, such as pancreatic and bladder tumors, as well as triple negative breast cancer (TNBC).