CD2


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia.

CD2

a type I transmembrane protein found on thymocytes, T cells, and some natural killer cells that acts as a ligand for CD58 and CD59 and is involved in signal transduction and cell adhesion; expressed in T-cell acute lymphoblastic leukemia and T-cell lymphoma.

CD2

A cell adhesion molecule found on the surface of natural killer cells and T cells that is critical for stabilizing contacts between T cells and antigen-presenting cells. It is used clinically as a biomarker in the laboratory evaluation of some leukemias and lymphomas.
See: cluster of differentiation

CD2

cluster of differentiation or cell differentiation glycoproteins.

CD antigen
a group of cell surface molecules which act as markers on T lymphocytes.
CD3
found on T helper (Th) and T cytotoxic (Tc) lymphocytes; associated with signal transduction.
CD4
found on T helper lymphocytes; an adhesion molecule that binds to class II MHC molecules.
CD8
found on T cytotoxic and variably on NK lymphocytes; an adhesion molecule that binds to class I MHC molecules.
References in periodicals archive ?
Using PE-conjugated antibodies, CD2 was expressed by mast cells in 13 of 19 cases (68%), and CD25 was expressed in 17 of 19 cases (89%).
10,11) Normal mast cells are consistently negative for CD2 and CD25.
CD2 is a cell adhesion molecule belonging to the immunoglobulin gene superfamily, which mediates transient adhesion of T cells to both antigen-presenting cells and target cells.
The current World Health Organization classification system criteria state that aberrant expression of CD2, CD25, or both by mast cells is an important characteristic of SM.
As a part of this study, we compared different fluorochromes conjugated with CD2 or CD25, we contrasted flow cytometry immunophenotyping with immunohistochemistry, and we assessed mast cells at the time of initial diagnosis of SM, as well as in follow-up samples with minimal residual disease after therapy.
Regarding CD2 expression by neoplastic mast cells, we show that immunohistochemistry is less sensitive than flow cytometry immunophenotyping (39% versus 61%).
En tubos de ensayo de 50ml se colocaron 21,42ml de cada uno de los diferentes extractos enzimaticos con 8,57ml de CD2 conteniendo 175mg x [l.
donde Abs CD2: absorbancia registrada del colorante a la longitud de onda de maxima absoreion del CD2 (480nm), y Abs Extracto: absorbancia a 480nm de la mezcla (extracto crudo y CD2), despues de un tiempo dado de reaccion.
En todas las determinaciones espectrofotometricas se utilizo como cero, el blanco correspondiente a cada mezcla de reaccion, el cual se preparo con extracto crudo y agua esteril en la misma proporcion en volumen que en los ensayos enzimaticos con CD2.
1] de micelio molido, a los que se adiciono CD2 en una concentracion de 100mg x [l.
Esto evidencia que las enzimas intracelulares y las asociadas al micelio pueden degradar al CD2 sin intervencion de las enzima extracelulares, contrario a lo que comunmente se ha reportado sobre la degradacion de compuestos azo (Koroleva et al.
En las Figuras 4 y 6 se aprecia que la decoloracion del CD2 se incremento a medida que aumento la concentracion de micelio molido; sin embargo, la capacidad de adsorcion maxima para cada concentracion fue muy similar 9,97; 10,37 y 10,08mg CD2/g de micelio, en 3h de contacto del micelio con el colorante.