The two classical histological features include scattered histiocytes with emperipolesis, which represent histiocytic phagocytosis of intact plasma cells, lymphocytes, and cellular debris as well as expression of S100 protein, CD14, CD68, and CD1c
and absence of staining for CD1a and MHC-2 (which are both positive for Langerhans-type dendritic cells).
Nickoloff, "Distinctive dendritic cell subsets expressing factor XIIIa, CD1a, CD1b and CD1c
in mycosis fungoides and psoriasis," Journal of Cutaneous Pathology, vol.
In humans, two dermal DC subsets are also identified, depending on the expression pattern of CD1a, CD1c
, and CD141 ([CD1a.sup.+][CD1c.sup.+] dermal DCs and [CD1a.sup.+] [CD141.sup.+] dermal DCs).
Estas celulas tambien expresan CD1a, CD1b, CD1c
y cadherina E, lo que permite su diagnostico por inmunohistoquimica (5,12,14) .
Abbreviations, CD numeration, and alternate names: DEC-205 (CD205), B220 (CD45R), PDCA-1 (plasmacytoid DC Ag-1; CD317; Bst2), Siglec H (Sialic acid-binding immunoglobulin-like lectin H), Langerin (CD207), CD141 (BDCA-3), CD1c
(BDCA-1), and CD303 (BDCA-2).
The differences between patients and controls appear quite weak with only 14 genes out of 18271 that appear to be differentially expressed (PMEPA1, TLR10, TRAF3IP2, LDOC1L, CD1C
, and EGR1) .
In the present study, we aimed to investigate the density of dendritic cells expressing CD1a, CD1c, DC-SIGN, and DC-LAMP.
Immunohistochemistry was performed using the following monoclonal antibodies: CD1a, CD1c, DC-LAMP, and DC-SIGN.
Human group 1 CD1 molecules, CD1a, CD1b and CD1c
, bind microbial glycolipids as well as self-glycolipids including GM1, and present the antigens to T-cells and NKT cells.
Group I is composed by CD1a, CD1b, and CD1c isoforms, group II by CD1d, and group III by CD1e.
CD1a is also expressed on Langerhans cells and CD1c in a subset of B cells .
He, "Human yd T cell recognition of lipid A is predominately presented by CD1b or CD1c
on dendritic cells," Biology Direct, vol.