CD1c

CD1c

a type I transmembrane protein found on cortical thymocytes, dermal cells, and brain astrocytes that is involved in nonclassical antigen presentation or is a receptor for an undefined ligand or hormone; expressed in patients with T-cell acute lymphoblastic leukemia, B-cell chronic lymphocytic leukemias, and B cells in severe combined immunodeficiency disease.
References in periodicals archive ?
The two classical histological features include scattered histiocytes with emperipolesis, which represent histiocytic phagocytosis of intact plasma cells, lymphocytes, and cellular debris as well as expression of S100 protein, CD14, CD68, and CD1c and absence of staining for CD1a and MHC-2 (which are both positive for Langerhans-type dendritic cells).
Nickoloff, "Distinctive dendritic cell subsets expressing factor XIIIa, CD1a, CD1b and CD1c in mycosis fungoides and psoriasis," Journal of Cutaneous Pathology, vol.
In humans, two dermal DC subsets are also identified, depending on the expression pattern of CD1a, CD1c, and CD141 ([CD1a.sup.+][CD1c.sup.+] dermal DCs and [CD1a.sup.+] [CD141.sup.+] dermal DCs).
Abbreviations, CD numeration, and alternate names: DEC-205 (CD205), B220 (CD45R), PDCA-1 (plasmacytoid DC Ag-1; CD317; Bst2), Siglec H (Sialic acid-binding immunoglobulin-like lectin H), Langerin (CD207), CD141 (BDCA-3), CD1c (BDCA-1), and CD303 (BDCA-2).
The differences between patients and controls appear quite weak with only 14 genes out of 18271 that appear to be differentially expressed (PMEPA1, TLR10, TRAF3IP2, LDOC1L, CD1C, and EGR1) [176].
In the present study, we aimed to investigate the density of dendritic cells expressing CD1a, CD1c, DC-SIGN, and DC-LAMP.
Immunohistochemistry was performed using the following monoclonal antibodies: CD1a, CD1c, DC-LAMP, and DC-SIGN.
Human group 1 CD1 molecules, CD1a, CD1b and CD1c, bind microbial glycolipids as well as self-glycolipids including GM1, and present the antigens to T-cells and NKT cells.
Group I is composed by CD1a, CD1b, and CD1c isoforms, group II by CD1d, and group III by CD1e.
CD1a is also expressed on Langerhans cells and CD1c in a subset of B cells [5].
He, "Human yd T cell recognition of lipid A is predominately presented by CD1b or CD1c on dendritic cells," Biology Direct, vol.