CD1b

CD1b

a type I transmembrane protein found on cortical thymocytes, dermal cells, and brain astrocytes that is involved in nonclassical antigen presentation or is a receptor for an undefined ligand or hormone; expressed in patients with T-cell acute lymphoblastic leukemia, T-cell lymphoma, and thymomas.
References in periodicals archive ?
For instance, heavy chains of CD1b are detained in the ER in [sz]2M-deficient cells,[sup][92] however, a portion of CD1d heavy chains can exit the ER and reach the cell surface independent on[sz]2M.
Assembly and retention of CD1b heavy chains in the endoplasmic reticulum.
Ademas, la molecula CD1e juega un papel importante al facilitar el acoplamiento de los lipidos a moleculas como CD1d y CD1b.
Group I is composed by CD1a, CD1b, and CD1c isoforms, group II by CD1d, and group III by CD1e.
CD1b has two additional pockets, C' and T' that allow the binding of lipids with larger hydrophobic chains [11].
CD1b and mouse CD1d (mCD1d) interact with AP-3, which sorts these molecules to the late endosomes and lysosomes.
However, CD1b was found to be associated with rather small lipids that do not fully occupy the binding pocket.
Estas celulas tambien expresan CD1a, CD1b, CD1c y cadherina E, lo que permite su diagnostico por inmunohistoquimica (5,12,14) .
El uso de inmunohistoquimica determina el diagnostico definitivo, con la expresion de CD1a, CD1b, CD 1c, complejo mayor de histocompatibilidad (CMH) y cadherina E, con snap tisular.
Las moleculas clase I del MHC, presentes en todas las celulas del organismo estan preferentemente en las vacuolas autofagicas (3); las moleculas clase II del MHC, caracteristicas de las APC profesionales se pueden evidenciar en varias estructuras, tales como los granulos con caracteristicas de hoja de cebolla (en CE), las del CD1a y CD1b en las vesiculas recubiertas por clatrina (CE, CD); la lectina langerina en los granulos de Birberck (CL), enzimas para la degradacion de los antigenos a moleculas pequenas se encuentran en los lisosomas (CE, CL), que se identifican por su actividad de fosfatasa acida (1,3,12-14), otras enzimas en los microcuerpos (no descritos previamente en la mucosa bucal) y en pequenos granulos con material electrodenso.
Human group 1 CD1 molecules, CD1a, CD1b and CD1c, bind microbial glycolipids as well as self-glycolipids including GM1, and present the antigens to T-cells and NKT cells.
The manose receptor delivers lipoglycan antigens to endosomes for presentation to T cells by CD1b molecules.