Cells in LCH express
CD1a and ultrastructurally, Birbeck granules.
Immunohistochemical staining for S-100 protein and
CD1a confirmed that the histiocytic cells were Langerhans' cells.
Mast cells, however, lack the typical nuclear grooves seen in Langerhans cells and do not react with the Langerhans cell markers S100,
CD1a, fascin, and Langerin.
Langerhans cells stain for S100 protein and
CD1a but are generally negative for CD45.
4) Moreover, in all of our patient's biopsies, the immunohistochemical studies were consistent with RDD, including CD68 and S100 protein labeling of histiocytes and lack of
CD1a expression.
The SHML histiocytes are positive for S100 protein and negative for
CD1a by immunohistochemistry.
Terminal deoxynucleotidyl transferase, CD34, and
CD1a each suggest an immature T-lymphoid process, with TdT the most likely to be present (Figure 3, d).
Other positive immunostaining patterns are reported with
CD1a, CD10, desmin, S100 protein, and caldesmon.
Tumors derived from Langerhans cells, such as Langerhans cell sarcoma, typically stain for
CD1a and S100.
A second panel of immunostains showed negativity for CD34, terminal deoxynucleotidyl transferase, myeloperoxidase, muramidase (lysozyme),
CD1a, and desmin, prompting consideration of a microphthalmia-associated transcription factor-positive, CD117-positive metastatic melanoma that had otherwise lost antigen expression.
Infiltrasyon icerisinde
CD1a ve S100 pozitif cok sayida Langerhans hucresi bulunabilir.
LHH'de immunohistokimyasal olarak S-100 ve
CD1a ekspresyonu tipiktir.
