CCR7

(redirected from CD197)

CCR7

A gene on chromosome 17q12-q21.2 that encodes a member of the beta chemokine receptor family, which is similar to G protein-coupled receptors. CCR7 is expressed in various lymphoid tissues and activates B and T lymphocytes. It controls migration of memory T cells to inflamed tissues and stimulates dendritic cell maturation.
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Antibody mix 1: CD3 PerCP Cy5.5 (BD552852), CD4 V450 (BD560345), CD8 V500 (BD560774), CD197 Alexa Flour 647 (BD557734), CD45RA PE Cy7 (BD560675), CD183 Alexa 488 (BioLegend 353710), and CD196 PE (BioLegend 353410)
Negative markers CD80 (12-1639-42, eBioscience) and CD197 (130-093-621, Miltenyi Biotec), typically expressed by M1 macrophages, were used to guarantee differentiation towards the M2 phenotype.
The absence of CD80 and CD197, both expressed by M1-phenotypes, verified induced M2 cell identity.
CD14 CD68 CD80 CD163 CD197 CD206 1 98.6 98.1 0.0 92.8 0.0 88.5 2 98.7 99.0 0.0 88.2 0.0 89.8 3 99.4 89.8 0.0 97.9 0.0 93.7 4 98.8 89.4 0.0 95.2 0.0 95.5 5 97.7 75.1 0.0 91.2 0.0 82.7 Mean 98.6 90.3 0.0 93.1 0.0 90.0 SD 0.6 9.6 0.0 3.7 0.0 5.0
Two main types, the large myeloid-derived DC (mDC) and the small plasmacytoid DC (pDC), upregulate the expression of coregulatory and costimulatory molecules (HLA-DR, CD40, CD80, and CD86) and the lymph node homing (LNH) molecules (CD197), enhancing adaptive immunity [35-37].
The expression of CD80, CD86, and LNHR CD197 on the [mDC1s.sup.high] were unaltered (Table 13).
Comparison of blood levels of mDC1 expression of costimulatory and LNH molecules between GPRs and PPRs showed a significant reduction in CD40, CD86, and CD197 expression on circulating mDC1s (p = 0.005, p = 0.004, and p = 0.003, resp.) following NAC in patients whose tumours had a PPR (Table 16).
Anti-human monoclonal antibodies specific for apoptotic/inhibitory molecules (CD95 (Fas/Apo1), CD152 (CTLA-4), CD279 (PD1), CD274 (PD1-L), and CD357 (GITR)), activation molecules (CD25 (sIL2Ra), CD69, CD71, and HLA-DR), chemokine and homing receptors (CD194 (CCR4), CD197 (CCR7), and CD62L (L-selectin)), integrin (CD103 ([alpha]E[beta]7)), ectonucleotidase (CD39 (ENTPD1), CD73 (57NT)), naive (CD45RA), costimulatory molecules (CD40L (CD154), CD28, CD40, CD70, CD278(ICOS), and CD137 (4-1BB)), and immunoregulatory cytokines (IL10, TGF-[[beta].sub.1]) were used.