CCR5

(redirected from CD195)
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CCR5

A gene on chromosome 3p21.31 that encodes a member of the beta chemokine receptor family, which is similar to G protein-coupled receptors. CCR5 is expressed by T cells and macrophages; it is a receptor for various CC-chemokines, including MIP-1-alpha, MIP-1-beta and RANTES, and transduces a signal by increasing the intracellular calcium ion level. CCR5 may play a role in the control of granulocytic lineage proliferation or differentiation, and is an important co-receptor for macrophage-tropic viruses (e.g., HIV-1) entering host cells.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

CCR5

A chemokine receptor; defects in its structure caused by genetic mutation cause the progression of AIDS to be prevented or slowed.
Mentioned in: AIDS
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
The report provides comprehensive information on the C-C Chemokine Receptor Type 5 (C-C CKR-5 or CHEMR13 or HIV-1 Fusion Coreceptor or CD195 or CCR5), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
* The report provides a snapshot of the global therapeutic landscape for C-C Chemokine Receptor Type 5 (C-C CKR-5 or CHEMR13 or HIV-1 Fusion Coreceptor or CD195 or CCR5)
Chemokine receptors CXCR4 (CD184) and CCR5 (CD195) are predominant coreceptors for HIV-1 entry into human's cells.