Leukocyte Adhesion Deficiency-I (LAD-I) is a rare, autosomal recessive pediatric disease caused by a mutation of the ITGB2 gene that encodes for the Beta-2 Integrin component CD18
is a key protein that facilitates leukocyte adhesion and enables their extravasation from blood vessels to combat infections.
integrin dependent endothelial injury: effects of opsonized zymosan and phorbol ester activation.
Leukocyte adhesion deficiency (LAD) is a rare primary immunodeficiency disorder with autosomal recessive inheritance which is characterized by presence of a defect of phagocytic function resulting from a lack of leukocyte cell surface expression of b2 integrin molecules (CD11 and CD18
) that are essential for chemotaxis.
CR3, also called CD11b/ CD18
or mac-1, is a receptor for iC3b  and is uniquely expressed by microglia in the CNS [15, 27-29].
(35) discovered the dysfunction of Treg cells by CD18
knockout (CD18hypo PL/J mice) as a causal factor of pathogenic T cell hyperproliferation in psoriasis.
They also decrease the expression of adhesion molecules CD11b and CD18
which are found on activated neutrophils and support neutrophil adhesion to endothelial cells.
CD11a, a cell adhesion molecule involved in cellular adhesion and costimulatory signaling, and that combines with CD18
to form the integrin lymphocyte function-associated antigen-1 (LFA-1) was expressed on all leukocytes.
By the way, I always keep one lipped diver such as a Rapala CD18
or Yo-Zuri Hydro Mag in the back of my natural bait spread.
The subunit coded by [beta]2 (CD18
) is a typical leukocyte marker (e.g., also on microglia), and also the absence of [alpha]6 in NCCs is consistent with other findings, e.g., in the chicken a6 expression is downregulated at the onset of NCC migration and re-expressed upon neuronal differentiation (Bronner-Fraser et al., 1992; Testaz et al., 1999).
McKnight, "A monoclonal antibody against the CD18
leukocyte adhesion molecule prevents indomethacin-induced gastric damage in the rabbit," Gastroenterology, vol.
Kijlstra, "Label-free proteomics reveals decreased expression of CD18
and AKNA in Peripheral CD4+ T Cells from patients with Vogt-Koyanagi-Harada syndrome," PLoS ONE, vol.