CD163

CD163

A transmembrane protein encoded by CD163 on chromosome 12p13.3, which mediates the endocytosis of haptoglobin-haemoglobin complexes. CD163 belongs to the cysteine-rich scavenger receptor superfamily
Normal expression Highly expressed by tissue macrophages and less so by circulating monocytes. In a soluble form in plasma, it has an anti-inflammatory function.
Abnormal expression Expression is upregulated during inflammation by glucocorticoids, IL-10 and other modulators.

CD163

A cell surface glycoprotein used in immunohistochemistry to identify monocytes and macrophages.
See: cluster of differentiation
References in periodicals archive ?
Immunohistochemically strongly positive for S100 protein and various markers especially CD68 and CD163.2 Painless cervical lymphadenopathy with or without extra nodal manifestations are among the most common clinical presentations.3 About 40% of Rosai-Dorfman disease cases have extranodal involvement with predominant head and neck region.
Genetically edited pigs lacking CD163 show no resistance following infection with the African swine fever virus isolate, Georgia 2007/1.
In our study, CD163 and CD206 expression, markers of alternative activated macrophages (M2), did not correlate with tolerance and cytokine production in LPS-tolerant human monocytes (50).
CD163: a specific marker of macrophages in paraffin-embedded tissue samples.
Subsequently, sections were stained with primary antibodies: mouse anti-human 11-Fibrau (1:100 for 60 min at RT), mouse anti-human CD68 (1:100 for 60 min at RT), mouse antihuman CD163 (1:25 for 60 min at RT), rabbit anti-human alpha smooth muscle actin ([alpha]-SMA) (1:400 overnight at 4[degrees]C), or rabbit anti-human Ki67 (1:100 for 60 min at RT).
They were also promising hotspots of macrophage polarization research related to 'dendritic cell,' 'injury,' 'CD163,' 'CD68,' 'deficiency,' 'mice,' and 'macrophage infiltration' [Figure 5]c.
At least one histiocytic or histiocyte-associated marker (CD163, CD68, CD11c, lysozyme) will be positive in cases of histiocytic sarcoma.
M2 macrophages express high levels of CD163, a hemoglobin-scavenger receptor, and can be used to discriminate between M1 and M2 macrophages (3).
Scientists used gene-editing techniques to remove a small section of the CD163 gene which the PRRS virus attaches to.
But by using gene editing techniques to remove a section of the CD163 gene the virus attaches to, the researchers found the pigs did not become infected.