KLRB1

(redirected from CD161)

KLRB1

A gene on chromosome 12p13 that encodes a C-type lectin domain protein which is expressed in natural killer (NK) cells and is involved in regulating their activity. KLRB1 inhibits NK-cell cytotoxicity and enhances anti-CD3-induced T-cell proliferation.
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Flow cytometric immunophenotype (FCI) comprised P1 cells with large forward scatter, expressing CD2/CD7, CD38, CD56, CD159a, CD161, and human leukocyte antigen-D related but negative for CD34, TDT, CD45, surface CD3, CDd5 CD138, CD19, and CD20, which indicated extranodal NKTCL.
In contrast, the effect of betamethasone dipropionate on the epidermis was restricted to a normalization of differentiation with a highly significant increase of keratin-10 positive epidermal surface without a significant effect on Ki- 67 positive nuclei, and the effect on T- cell subsets was restricted to a reduction of natural killer T-cell receptors designated by CD94 and CD161 in the epidermis.
Sadekova et al., "Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation," The Journal of Experimental Medicine, vol.
Increase of CD69, CD161 and CD94 on NK cells in women with recurrent spontaneous abortion and in vitro fertilization failure.
Flow cytometry (FCM) analysis of the BM aspirate cells using the EuroFlow lymphoid screening tube (LST) and antibody panel for NK cell chronic lymphoproliferative diseases (NK-CLPD) [7], complemented with other cell surface markers, showed that the neoplastic cells were positive for CD45 (high), CD2, CD26, CD38, CD94 (high), and HLADR (high, heterogeneous) antigens, and negative for surface CD3, TCR, CD4, CD5, CD7, CD8, CD11b, CD11c, CD16, CD56, CD57, and CD161, as well as for cytoplasmic CD3; in addition, they express intracellular granzyme B and perforin (Figure 3).
We used CD161 as a surrogate marker for Th17 cells (on [CD3.sup.+][CD4.sup.+] T cells) and we observed a decreased number of circulating Th17 cells in the patients with primary MCD in comparison to healthy controls.
Low expression of CD161 and NKG2D activating NK receptor is associated with Impaired NK cell cytotoxicity in metastatic melanoma patients.
Compared to MPB, only CD158a expression was significantly lower in APB and there wasn't a difference in the expression of CD161 and anti-Hu-KIR (p=0.0046).
In addition, IL-10KO DCs expressed greater levels of critical co-stimulatory and signaling molecules including B7.1, CCL27, CD161 and Calmodulin-dependent protein kinase when compared to WT DC.
Babovic, "In vitro increased natural killer cell activity of metastatic melanoma patients with interferon-a alone as opposed to its combination with 13-cis retinoic acid is associated with modulation of NKG2D and CD161 activating receptor expression," Journal of BUON, vol.
Perussia, "Differential transcriptional regulation of CD161 and a novel gene, 197/15a, by IL-2, IL-15, and IL-12 in NK and T cells," The Journal of Immunology, vol.