KLRB1

(redirected from CD161)

KLRB1

A gene on chromosome 12p13 that encodes a C-type lectin domain protein which is expressed in natural killer (NK) cells and is involved in regulating their activity. KLRB1 inhibits NK-cell cytotoxicity and enhances anti-CD3-induced T-cell proliferation.
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References in periodicals archive ?
Increase of CD69, CD161 and CD94 on NK cells in women with recurrent spontaneous abortion and in vitro fertilization failure.
1 para los humanos es el CD161, el cual define una poblacion iNKT CD161+ capaz de diferenciarse en celulas productoras de IL-17, ademas de expresar CCR6 y CCR4 como tambien el receptor para IL23.
Another subset is characterized by cells producing IL-17 that arise in response to proinflammatory conditions and express CD161 [108].
Low expression of CD161 and NKG2D activating NK receptor is associated with Impaired NK cell cytotoxicity in metastatic melanoma patients.
Compared to MPB, only CD158a expression was significantly lower in APB and there wasn't a difference in the expression of CD161 and anti-Hu-KIR (p=0.
1, CCL27, CD161 and Calmodulin-dependent protein kinase when compared to WT DC.
Human IL-25-and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161.
These cells can express CD56, CD161, human leukocyte antigen DR (HLA-DR), and NKG2D but without NKG2A and NKG2C [20].