BST1

(redirected from CD157)

BST1

A gene on chromosome 4p15 that encodes bone marrow stromal cell antigen-1, a glycosylphosphatidylinositol-GPI-anchored molecule that facilitates pre-B-cell growth by synthesising cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores.

Molecular pathology
The polyclonal B-cell changes in rheumatoid arthritis may be partly due to BST1 overexpression in stromal cells.
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References in periodicals archive ?
Functional role and prognostic significance of CD157 in ovarian carcinoma.
They found a highly abundant glycoprotein, called CD157, expressed in the small fraction of EC population.
Citation: Taku Wakabayashi et al., "CD157 Marks Tissue-Resident Endothelial Stem Cells with Homeostatic and Regenerative Properties," Cell Stem Cell, 2018; DOI: 10.1016/j.stem.2018.01.010
We recently demonstrated that [CD56.sup.bright]CD16-NK cells express high levels of CD39, CD73, CD203a/PC-1, and CD157, as compared with the [CD56.sup.dim]CD16+ NK subset.
The same study pointed out that MSC also express CD38, CD157, and CD203a/PC-1 [21].
A recent study used CD157 KO mice, a PD genetic model displaying depression- and anxiety-like behaviors, to explore the antidepressant and anxiolytic effects of selegiline, an irreversible monoamine oxidase-B (MAO-B) inhibitor.
Other approaches for Sirt activation involve [NAD.sup.+] precursors, such as nicotinamide riboside or nicotinamide mononucleotide [71], and augmentation of [NAD.sup.+] availability via inhibition of glycohydrolases CD38 and CD157, which convert [NAD.sup.+] to nicotinamide mononucleotide [72].
CD38 belongs to an increasingly recognised large number of lymphocyte ecto-enzymes (CD157, CD39 and CD73), which are involved in adenosine triphosphate (ATP) and nicotinamide adenine dinucleotide (NAD) metabolism.
Malavasi, "The human CD38 gene: polymorphism, CpG island, and linkage to the CD157 (BST-1) gene," Immunogenetics, vol.
Ferrero et al., "CD38 and CD157 as receptors of the immune system: a bridge between innate and adaptive immunity," Molecular Medicine, vol.