ADAM1aia8

(redirected from CD156)

ADAM1aia8

An ADAMs family protein encoded by ADAM8 on chromosome 10q26.3. It functions as an osteoclast stimulating factor. It is expressed in granulocytes, monocytes, macrophages and may play a role in extravasation of leukocytes. ADAM 8 is involved in cell-cell and cell-matrix interactions; the soluble form cleaves myelin basic protein and may be involved in cell adhesion during neurodegeneration.
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References in periodicals archive ?
We have analyzed the distribution and association between the previously described polymorphisms of cd156 (silent nucleotide substitution), cd312 and cd751 (non-conservative amino acid substitutions) in XPD gene of rural Maharashtrian population.
MSCs are considered immune-privileged because they express immunostimulatory molecules, such as CD40, CD156, CD80, CD86, and HLA molecules, at low levels [48].
In addition, expression of inflammatory genes in adipose tissue such as Tnf-[alpha], Mcp-1, and IL-1[beta] (Interleukin-1 beta) as well as that of specific macrophage markers such as Cd68 (macrophage antigen Cd68, also known as scavenger receptor class D member 1, Scard1), F4/80 (also referred to as lymphocyte antigen-71, Ly71), and Adam8 (ADAM metal-lopeptidase domain 8, also known as cluster of differentiation molecule-156, Cd156) in the stromal vascular fraction was more pronounced in Ppar[alpha]-deficient mice compared to WT (wild-type) mice rendered obese with a high-fat feeding, reinforcing the notion that PPAR[alpha] is required for the control of the adipose inflammation process [63].