CD40LG

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CD40LG

A gene on chromosome Xq26 that encodes of a protein expressed on the surface of T cells which regulates B-cell function by binding CD40 to the B-cell surface. CD40LG is critical for immunoglobulin class switching. 

Molecular pathology
A defect in CD40LG is associated with hyper IgM syndrome due to an inability to undergo class switch.
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22] demonstrated that NCL acts as a key component of the complex involved in maintaining CD154 mRNA stability and regulating mRNA turnover in activated T-cells.
The following wheat cultivars were evaluated: CD104, CD108, CD116, CD150, CD154, CD1440, CD1550, BRS Guamirim, BRS Pardela, Mirante and Quartzo, intended for grain production.
Mycobacterial infections are observed commonly in patients with severe forms of primary immunodeficiency, including severe combined immune deficiency (SCID), complete Di George syndrome, X-linked hyper immunoglobulin (Ig)-M syndrome (HIGM type 1, CD154 deficiency), CD40 deficiency, immune deficiencies accompanying ectodermal dysplasia (nuclear factor kappa-beta essential modulator (NEMO), IKBA), chronic granulomatous disease (CGD), interleukin 12-interferon gamma (IL-12/IFN-[gamma]) receptor disorders, and hyper IgE syndrome, and these diseases have been examined under the title of Mendelian Susceptibility to Mycobacterial Diseases (MSMD) (3-12).
Cuando el factor nuclear se transloca al nucleo, se induce la expresion de CD154 (CD40L) en el linfocito T, siendo en gran parte el responsable de la activacion policlonal de celulas B y de la sobreproduccion de anticuerpos por un mayor contacto entre linfocitos T y linfocitos B (11).
Blocking the interaction between CD40 and CD154 by anti-CD154 or anti-CD40 antibody has been found to be beneficial in several animal models of autoimmune diseases and transplantation [6,7].
Experimentos ex vivo han demostrado que las plaquetas aisladas de pacientes con LES estan activadas, por la sobre expresion de CD154, y estos niveles de CD154 se correlacionan con la severidad de la enfermedad.
Enhanced levels of CD154 (CD40 ligand) on platelets in patients with chronic heart failure.
CD40 and the B7 family proteins (CD80, CD86, and others), which are expressed on "antigen presenting cells", bind to CD154 and CD28 or CTLA-4, respectively, ligands which are expressed mainly on responding T cells.
4) They include antibodies against T-cell marker of Tumor Necrosis Factor (TNF) family: CD154 and thrombopoietin (TPO) protein agonists.
Induction of a CD4+CD25+ T cell subset following blockade of CD154 in a Phase I clinical trial in RRMS.
University of California (Oakland, CA) has patented an isolated polynucleotide sequence encoding a chimeric CD154, comprising a first nucleotide sequence encoding an extracellular subdomain of non-human CD154, preferably murine CD154, that replaces a cleavage site of human CD154, and a second nucleotide sequence encoding an extracellular subdomain of human CD154 that binds to a human CD154 receptor.