CD15


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CD15

a phosphatidylinositol-anchored transmembrane protein found on neutrophils; it may be involved in phagocytosis; expressed in patients with Hodgkin disease, some B-cell chronic lymphocytic leukemias, acute lymphoblastic leukemias, and most acute nonlymphocytic leukemias.
Farlex Partner Medical Dictionary © Farlex 2012

CD15

This is a retired HUGO symbol for what molecular biologists now term FUT4 (see there). In practice, CD15 is widely used by haematologists, immunologists, laboratorians, pathologists and many others.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
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(A) Genome browser view displays tracks from top: Refseq gene AHRR; CpG Islands; C14+ Monocyte DMRs (black bar); differentially methylated CpGs ([DELTA] Methylation %) in CD14+ monocytes (CD14+ Mono) and CD15 + granulocytes (CD15 + Gran), and histone modification data tracks from the Epigenome Roadmap Project(a) for each cell type: H3K4me3, histone H3 Lysine 4 trimethyl (active mark); H3K27ac, histone H3 Lysine 27acetyl (active enhancer); H3K4me1, histone H3 Lysine 4 monomethyl (enhancer); H3K27me3, histone H3 Lysine 27trimethyl (repressive mark).
(a) mRNA expression of eight stem cell markers (Nestin, CXCR4, Oct3/4, CD15, CD133, Bmi-1, Sox2, and CD44) and four stem cell-related molecules (HIF-1[alpha], HIF-2[alpha], VEGF, and TGF-[beta]) in the core and the periphery was determined with qRT-PCR.
In contrast, CD15 was detected in high rates of both urachal and primary bladder adenocarcinomas (86% and 73%, resp.) compared to colorectal adenocarcinomas with a lower reactivity rate (<50%) [21, 27, 124, 125, 348].
(3-5,7) In the present case the HRS cells were CD30+, CD20+, CD79a+ but CD15 was negative as may occur in these lymphomas.
Interestingly, besides an increase in neutrophil number, as seen in experimental data from hypercortisolemic conditions [27, 28], the neutrophils of all CS patients showed a tendency to express activation markers like FC receptor CD16 and tetrasaccharide adhesion marker CD15, an association that persists in multiregression analysis.
Bone marrow biopsy and aspirate showed 73% myeloblasts and immature promonocytes expressing CD13, CD15, CD33, CD45, CD64, CD123, and HLA-DR by immunohistochemistry (IHC) and flow cytometry (FC).
Reed- Sternberg-like and histiocyte-like cells displayed CD68 (Figure 1D) and Mac387 expression; however, no reaction was determined with CD15 (LeuM1) and CD30 (Ki-1).
Pericardial biopsy revealed multiple nodules with interstitial hyalineosis containing a polymorphic infiltrate of small lymphocytes, rare eosinophils and Reed-Sternberg cells with CD30 and CD15 positivity (Figure 2).
All cases of lymphoma were CD20 positive, CD5, CD15, and CD30 negative and the patients were diagnosed with diffuse large B-cell lymphoma [Table 3].
The panel of lymphoid antibodies included: TdT, CD34, CD45, CD19,CD20, CD79, MUM-1 CDI0 ,CD21, CD23, CD3 ,CD4, CD5, CD8, CD15, CD30, CD43, CD56,CD68, MPO, Ki-67, Bcl-2, Bcl-6, Cyclin D1, Kappa, Lamda, ALK-1, ZAP 17 were used.