PDGFRA

(redirected from CD140a)

PDGFRA

A gene on chromosome 4q12 that encodes a tyrosine-protein kinase which acts as a cell surface receptor for PDGFA, PDGFB and PDGFC, playing a key role in regulating embryonic development, survival and chemotaxis and, depending on context, up- or downregulates cell proliferation and migration.
References in periodicals archive ?
[35] showed that [CD34.sup.+] cells obtained from AT also express the pericyte markers NG2, CD140a, and CD140b, are located in the peri-vascular region in vivo, and interact with ECs to form tubular structures in vitro.
Citation: "CD140a identifies a population of highly myelinogenic, migration-competent and efficiently engrafting human oligodendrocyte progenitor cells;" Fraser J.
Sim and Rochester graduate student Crystal McClain ran extensive analyses looking at gene activity in different types of stem cells, leading to the conclusion that stem cells carrying a protein known as CD140a on their surface seemed to be most likely to become the desired cells: oligodendrocytes.