CD14


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CD14

a transmembrane protein found on monocytes, macrophages, neutrophils, some B cells, and dendritic cells that is involved in signal transduction leading to oxidative burst and/or synthesis of tumor necrosis factor-α; expressed in some patients with acute nonlymphocytic leukemia and in B-cell chronic lymphocytic leukemia.
Farlex Partner Medical Dictionary © Farlex 2012
References in periodicals archive ?
However, the neoplastic cells were negative for CD14 in all cases (Figure 2, e).
The objective of this research was to isolate porcine LBP and CD14 genes, to analyze their tissue distribution and to screen their polymorphisms.
The reliability coefficients were substantially to highly repeatable (R > 0.60) for CD14, TLR-2, CD 162, CD61, CD62P, CD41, CD 154, and all cell aggregates.
The researchers extracted enough CD14 protein from the inoculated plants for field tests.
TLR4 was also recognized as the predominant signaling receptor for LPS in human blood, whereas CD14, which is incapable of signal transduction across cell membrane, enhances TLR-mediated cell activation (Tapping et al.
Subsequent analyses have established the relationships between endotoxin, CD14, and TLR4 (see figure 2).
Role of CD14 and TLR4 in type I, type III collagen expression, synthesis and secretion in LPS-induced normal human skin fibroblasts.
The International Society for Cellular Therapy (ISCT) has recommended minimal criteria for identifying MSCs, which included plastic-adherence, trilineage differentiation capacity (osteogenic, adipogenic, and chondrogenic), positive expression of CD105, CD73, and CD90, and negative expression of CD45, CD34, CD14 or CD11b, CD79a or CD19, and HLA-DR [25].
To unravel the difference in the phenotypic signature between T Mo and A Mo, we compared the levels of CD14, CD16, ICAM-1, CCR2, and HLA-DR on these two subpopulations in patients and controls (Figure 3(a), Table 2).
Macrophages express a repertoire of pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs), CD14, nucleotide-binding oligomerization domain-like (Nod-like) receptors, and RIG-I-like receptors [11-15].