FLT3

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FLT3

A gene on chromosome 13q12 that encodes a class-III receptor tyrosine kinase, which regulates haematopoiesis. FLT3 is activated by binding the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase in turn phosphorylates and activates multiple cytoplasmic effectors involved in apoptosis, proliferation and differentiation of haematopoietic cells in bone marrow.

Molecular pathology
FLT3 mutations that activate the receptor are thought to induce acute (myeloid or lymphocytic) leukaemia.
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In the study by Tsiganov and coauthors, the cells coexpressed neutrophilic (Gr-1, Ly-6G), monocytic (F4-80), and myeloid (CD11b) cell markers and had immaturity signs, such as increased expression of CD117, CD135, and unsegmented nuclei.
It has been demonstrated that cells that in Mtb-infected mice fall into the "[Gr-1/Ly-6G.sup.hi]" gates (TBAN) differ from [Gr-1/Ly-6G.sup.hi] neutrophils found in steady-state conditions ("steady-state neutrophils" (SSN)): TBAN had lower expression levels of Gr-1/Ly-6G, elevated expression of immaturity markers CD115 and CD135, and, in contrast to SSN, were able to inhibit T cell proliferation [102].
For all engines shipped after about December 1, 2015, the approved TBR increases to 2100 hours from the previous 1500 hours for the CD135 engine and 1200 hours for the higher-output CD155 that finds application in the Piper Archer DX and the announced Cessna 172TD.
Adding it all up, including oil changes and other required replacement items, yields a total direct operating cost of $100,430 for the CD135 or $47.70 per operating hour using data provided by Continental and a Jet A average price of $4.07 a gallon in the U.S.
We spoke to three companies doing diesel conversions using the CD135 engines and none were particularly bullish that longer TBRs will nudge loose latent demand.
Ravel's Piano Trio in A minor by the Ahn Trio (Chesky CD135) was a little rounder and softer sounding on the Mach 1.
After coculture for 3 days, cells in the upper chamber were collected and incubated with CD34, CD38, CD135, and CD45RA antibodies (BD Pharmingen, San Diego, CA) to assess the percentage of common myeloid progenitor (CMP), Megakaryocyte-erythroid progenitor (MEP), and granulo-monocytic progenitor (GMP).
Thus, the negative surface markers, such as CD11b, CD31, CD45, CD48, CD90, CD106, CD117, and CD135, should be described together [17, 19].
A decrease in hematopoietic markers was observed, with some markers losing expression, such as CD31 (0%), CD45 (0.64%), and CD38 (0%); some that had low expression had the marking lost as CD144 (0%), CD135 (0%), and KDR (0%), and others had a drastic fall in the percentage of positive cells, such as CD34 (27.4%), CD43 (10%), and CD235a (4.95%).
Markers D + 0 D + 4 D + 8 D + 11 D + 14 EB D + 14 supernatant OCT4 86.86% 6.8% -- -- -- -- SOX2 98.34% 46% -- -- -- -- NANOG 87.4% 2% -- -- -- -- CD31 -- 0.6% 22.1% 0% -- -- CD144 -- 0.1% 5.7% 0% -- -- CD45 -- 0% 77.2% 0.6% 0.6% 0.8% CD34 APC -- 3.4% 58.3% 27% 24% 30.3% CD135 -- 0% 6.3% 0% 0% 0% CD43 -- 3.4% 29% 10% 0% 0% KDR -- 1% 1.8% 0% -- -- CD235a -- 19% 63.3% 5% 0% 0% CD38 -- -- 52.5% 0% 0% 0% CD117 -- -- 84% 0% 0% 0% CD41a -- -- -- -- 0% 0% CD42a -- -- -- -- 0% 0% EB: embryoid body; APC: allophycocyanin; KDR: kinase insert domain receptor.