IL2RG

(redirected from CD132)

IL2RG

A gene on chromosome Xq13.1 that encodes the gamma subunit of interleukin-2 (IL-2) receptor, which forms a heterotrimer with alpha and gamma subunits resulting in a high-affinity IL-2 receptor. The gamma chain is an important signalling component of many IL receptors, including those of IL-2, IL-4, IL-7 and IL-21, and is thus referred to as the common gamma chain.

Molecular pathology
Defects in IL2RG cause X-linked severe combined immunodeficiency (XSCID), as well as the less severe X-linked combined immunodeficiency (XCID).
References in periodicals archive ?
Increased plasma interleukin-7 level correlates with decreased CD127 and Increased CD132 extracellular expression on T cell subsets in patients with HIV-1 infection.
Now you can jump into a Focus or the new CD132 Mondeo in Europe, or the Escape in the U.
When I first drove an Escape, I was impressed by how similar it felt to the CD132 that I'd been developing in parallel in Europe.
CD132 was right in the ballpark in terms of hard points and offered a significant upside on cost; the downside was that it was FWD.