IL4R

(redirected from CD124)

IL4R

A gene on chromosome 16p12.1-p11.2 that encodes the alpha chain of the IL4 receptor, a type-I transmembrane protein which can bind IL4 and IL13 to regulate IgE production. ILR4 also binds IL4 to promote differentiation of Th2 cells.

Molecular pathology
Allelic variants in IL4R have been associated with atopy, which is accompanied by allergic rhinitis, sinusitus, asthma and eczema, as well as by Japanese cedar pollinosis.
References in periodicals archive ?
Genetic constitutions (16) were evaluated: i) commercial cultivars (4) ('BRS 331', 'Marfim', 'CD124' e 'BRS Parrudo'); ii) progenies [F.sub.1] (6), obtained by artificial crosses between cultivars forming a complete diallel, without the reciprocal ones; iii) progenies in generation [F.sub.2] (6), which were obtained by self-fertilization of progenies [F.sub.1] The parents (P1: 'BRS 331'; P2: 'Marfim'; P3: 'CD124'; e P4: 'BRS Parrudo') were selected for hybridization due to their contrasting characteristics and agronomic performances (Table 1).
Several biological markers characterize MSCs of different origins to be positive for CD73, CD105, CD29, CD44, CD71, CD90, CD106, CD120a, and CD124 and negative for CD117, CD34, CD45, and CD14 [19-21].