TNF RII/TNFRSF1B TNF RII (tumor necrosis factor receptor II), also known as TNFRSF1B, p75/p80, and CD120b
, is a widely expressed receptor for membrane-associated TNF-[alpha] and lymphotoxin-[alpha].
The cytokine has the ability to bind to the two isotypes of membrane receptors located on the surface of almost every nucleated cell TNF-R1 (p55, CD120a, and TNFRSF1a) and TNF-R2 (p75, CD120b
, and TNFRSF1b) [52, 53].
TNF[alpha] is capable of eliciting a variety of different immune responses by signalling via two types of membrane-bound receptors, type I (CD120a, TNFRSF1A) and type II (CD120b
, TNFRSF1B) receptors, with respective molecular weights of 55 and 75kDa [5, 6].