CD117


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CD117

a type I transmembrane protein present on hemopoietic progenitors, mast cells, melanocytes, spermatogonia, oocytes, and some natural killer cells; assists in signal transduction to transfected cell lines; expressed in colon carcinomas.
References in periodicals archive ?
Immunohistochemical examination was positive toward S100 antibodies (Figure 3), vimentin (Figure 4), and platelet-derived growth factor receptor alpha (PDGFRA) and negative toward CD34, CD117, smooth muscle antibody, DOG-1, and desmine.
(16) Stains for CK7, vimentin, CD117, RCC antigen, carbonic anhydrase IX, chromogranin, synaptophysin, cathepsin K, TFE3, and HMB45 usually show negative results.
The expression of characteristic myeloid lineage markers CD13, CD33 and CD117 allows the distinction of AML from other types of leukaemias.4 In the diagnosis of acute leukemia concordance between experienced observers increases from 70 to 99% when morphologic criteria are supplemented by cytochemical and immunophenotypic information.5 Immunophenotyping plays an important role when morphological interpretation is difficult.
The study is one of two indicating that an antibody targeting a protein called CD117 on the surface of blood-forming, or hematopoietic, stem cells can efficiently and safely eliminate the cells in mice and nonhuman primates.
Single Doses of Antibody Drug Conjugates Targeted to CD117 or CD45 Have Potent In Vivo Anti-Leukemia Activity and Survival Benefit in Patient-Derived AML Models.
Approximately 95% of sporadic GISTs are positive for CD117, 60% to 70% positive for CD34, and 30% to 40% positive for smooth muscle actin, whereas negative for S100 protein and desmin (3, 4).
When a tumor that is positive with the CD117 biomarker appears brighter than the rest of the kidney, it is more likely to be benign, the investigators explained.
Atypical cells CD2, CD3, CD5, CD7, and TIA1 were found positive, CD20, CD79a, and CD117 were found negative, and MPO myeloid cells were positive.
The immunohistochemical findings showed that CD117 was positive [Figure 1]b, of DOG1 was focally positive, and desmin, SMA, CD34, S-100, SOX10, and p53 were negative, and Ki-67 was 20%+ [Figure 1]c and 1d] suggesting high risk.{Figure 1}
Immuno-histochemical expression of diagnostic markers of GIST CD34, CD117 and DOG-1 were reassessed and documented.