CD117


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CD117

a type I transmembrane protein present on hemopoietic progenitors, mast cells, melanocytes, spermatogonia, oocytes, and some natural killer cells; assists in signal transduction to transfected cell lines; expressed in colon carcinomas.
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Immunohistochemical analysis showed local pan-cytokeratin (+), vimentin (+), P63 (−), cytokeratin 516 (−), CD34 (+), few scattering in the CD68 (+), Ki-67: 50%, the local smooth muscle actin (+), the local S-100 (+), estrogen receptor (−), progesterone receptor (−), E-cadherin (−), dosmin (−), actin (+), the local CD10 (+), and CD117 (−).
The monoclonal antibodies (MoAb) used for diagnosis of AL were: for B-lineage: CD19, CD22, CD20, CD10, for T-lineage: CD2, CD3, CD5, CD7, CD4, CD8, for myelo-monocytic lineage: CD13, CD33, CD11c, CD64, CD14, other cells surface markers: CD34, CD117, HLA-DR and intracellular MoAb: CD79a, CD3 and MPO.
Conclusions: CD117 expression itself can be used as a marker in differential diagnosis of salivary gland neoplasms.
Tumour cells were negative for CD117, DOG1, CD1a, SMA and ALK.
Flow cytometric analysis revealed approximately 82% of cells in blast region expressing dim CD13, heterogeneous CD117, moderate CD38, dim CD34, MPO positive, dim CD19, and negative for human leukocyte antigen - antigen D-related.
Tumor cells expressed immunohistochemical staining for CD34, CD117, lysozyme, and myeloperoxidase (figure 3).
CD117 expression is a sensitive but nonspecific predictor of FLT3 mutation in Tacute lymphoblastic leukemia and T/ myeloid acute leukemia.
On immunohistochemistry, the tumor cells were positive for vimentin, smooth muscle actin (figure 2B), and desmin and negative for S100, CD117, and CD34.
CD117 (KIT): a diverse protein with selective applications in surgical pathology.
6 Despite the widespread use of CD117 antibodies in this setting, there is no agreement on what constitutes a normal/abnormal number of ICC or what a normal/ disrupted network of ICC is?
C-KIT is a receptor tyrosine kinase protein also known as CD117 and has a role in cell survival, proliferation and differentiation (11) (Figure 2).