CD115

CD115

a type I transmembrane protein present on the placenta, macrophages, monocytes, and monocyte-precursors that is involved in proliferation and differentiation of monocytes and their progenitors; expressed in choriocarcinomas.
Farlex Partner Medical Dictionary © Farlex 2012
References in periodicals archive ?
Several studies have highlighted the significance of inflammation as an early event after stenting in different animal models using specific antibodies to leukocytes (CD45), macrophages (CD14), and monocytes (CD115).[18] The anti-inflammatory effect of DXM was by inhibiting lipopolysaccharide (LPS)-induced superoxide production than the production of nitric oxide and tumor necrosis factor-a (TNF-a).
Another characteristic of activated M2 monocytes is increased expression of CD206 and CD115 [12, 13].
Bone marrow [CD115.sup.+] monocytes were sorted by a CD115 microbead kit (Miltenyi Biotec, Bergisch Gladbach, Germany, catalog number 130-096-354) according to the manufacturer's instructions.
It also became clear that monocytes express RANK and c-fms (CD115), and the presence of their ligands RANKL and M-CSF, respectively, was necessary and sufficient for osteoclastogenesis to occur [8, 14, 15].
Introduction of additional markers allowed for further characterization of these subsets indicating that CD14lowCD16+ monocytes expressed higher levels of CD43, CD115, CXCL16, CXCR1 and C3AR1 expression whereas CD14highCD16- monocytes exhibited higher levels of CD1d, CD93 and CD114.
Phycoerythrin- (PE-) labeled anti-mouse F4/80 antibodies, allophycocyanin (APC)/Alexa Fluor 750-labeled anti-mouse CD11b antibodies, and APC-labeled anti-mouse CD115 antibodies in 25 [micro]L of cell staining buffer were added and allowed to react in darkness at 4[degrees]C for 15 minutes to identify the mononuclear leukocytes in the HMNC suspension.
Todas mis Esperansas, 1940s Recordings of Judeo-Spanish, Greek and Turkish Song, New York, Global Village CD115, 1998.
IL-34 is a newly discovered cytokine, which is consisted of 222 amino acids and shares the same receptor with macrophage colony-stimulating factor (M-CSF) [4, 5], also called colony-stimulating factor-1 receptor (CSF-1R or CD115).
Then, the cells were stained with antibodies to CD34 (Santa Cruz Biotechnology, USA), VEGFR-1 (Sigma-Aldrich, USA), CD115, CD117 (Abcam, USA), CD14, CCR2 (Santa Cruz Biotechnology), and CD90, CD44, STRO-1, OCT3/4, and Nanog, all from Abcam, at a concentration of 1 [micro]g/mL at 4[degrees]C for 30 min.
Cell suspensions were stained with the following appropriately labeled antibodies: CD11b, Ly6G- Ly6C, CD4, CD25, Foxp3, mPDCA-1, CD11c, CD115, MHC-II, CD80, and CD86 (BD Biosciences, Pont de-Claix, France).
As these [MHCII.sup.Int] [CD11b.sup.+] [CD11c.sup.+] have been referred to as more macrophage-like, we measured two surface markers: CD115, also known as M-CSF receptor, and MERTK.
It has been demonstrated that cells that in Mtb-infected mice fall into the "[Gr-1/Ly-6G.sup.hi]" gates (TBAN) differ from [Gr-1/Ly-6G.sup.hi] neutrophils found in steady-state conditions ("steady-state neutrophils" (SSN)): TBAN had lower expression levels of Gr-1/Ly-6G, elevated expression of immaturity markers CD115 and CD135, and, in contrast to SSN, were able to inhibit T cell proliferation [102].