CD107a

CD107a

a type I transmembrane protein present on activated platelets; increased expression noted on transformation of cells with metastatic potential and on embryonic cells.
Farlex Partner Medical Dictionary © Farlex 2012
References in periodicals archive ?
The most abundant lysosomal membrane proteins are lysosomal-associated membrane protein-1 (LAMP-1, CD107a), LAMP-2 (CD 107b), and LAMP-3 (CD63).
NK cells from GC patients exhibited a lower degranulation potential (CD107a expression) against K562 cells than those in healthy donors (Supplementary Figure 2).
In recent years, the absence or decreased intensity of CD107a measured on the cell surface by flow cytometry have high sensitivity and specificity for the diagnosis of the granule exocytosis primary disorder, which has been verified in CHS patients.
Surface staining of CD107a (Pacific Blue, LAMP-1, Clone H4A3, 0.25 [micro]g/sample) was used to study degranulation activity [8-13].
[33] recently showed that NKp46-activating antibodies activate NK cells and lead to degranulation and cytokine secretion, as indicated by CD107a and CD16 expression, and IFN-[gamma] secretion, respectively.
Further activation markers (CD13, CD107a, and CD164) were identified by Hennersdorf et al.
The CD107a degranulation assay was performed with media, extract or Erucin-treated purified NK cells (2x[l0.sup.5] for 24 h) and was further activated with 2x[l0.sup.4] K562 leukemia cells in U-bottom 96-well plates.
In addition, [CD8.sup.+] T cells generated in vivo also upregulated a classical marker of degranulation (CD107a) [29, 30] after stimulation with both peptide pulsed HepG2s and HBV chronically infected cell line HepDE19 (Figure 5(b)).
The CD107a (LAMP-1) PE conjugated antibody was from eBiosciences (cat#12-1071).
Lysosomal-associated membrane proteins 1 and 2 (LAMP-1, CD107a; LAMP-2, CD107b)LAMP-1 and 2 integral membrane glycoproteins are found in the lysosomes and dense granules of platelets and serve as markers of platelet activation.
The proposed model would integrate clinically obtainable data sources, for example: FACS counts of (CD16+/56+) cells, NK cell function (CD107a, K562), tumor size (CT scan), mAb concentration in blood, and downstream target inhibition (eg pERK).”
Lysosome-associated membrane proteins h-LAMP1 (CD107a) and h-LAMP2 (CD107b) are activation-depen dent cell surface glycoproteins in human peripheral blood mononuclear cells which mediate cell adhesion to vascular endothelium.