CD10

CD10

a type II transmembrane protein found on pre-B cells, germinal-center B cells, some neutrophils, kidney cells, T-cell precursors, and epithelial cells that acts as a zinc metalloprotease cleaving peptide bonds on the amino side of hydrophobic amino acids; expressed in acute lymphocytic leukemia and follicular-center-cell lymphomas.
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Immunophenotyping of these tumor cells reveals that they express surface immunoglobulins and B-cell antigens but lack CD5, CD10, and CD23.
Reactivation of doxorubicin occurs extracellularly in the tumor through enzymatic cleavage of the peptide by at least two enzymes: CD10 (Neprilysin / CALLA) and Thimet Oligopeptidase (TOP).
Since distinguishing SPN from neuroendocrine tumor can be difficult in some cases, using a selected panel of immunostains including b-catenin, CD10, synaptophysin, and chromogranin is highly recommended for the definite diagnosis.
The tumour was uniformly negative for CD10, desmin and alpha-smooth muscle actin.
Immunophenotypic characterization has determined the neoplastic cell expresses proximal tubule markers, such as CD10, RCC marker, [alpha]-methyl-acyl-coenzyme A (AMACR; also known as racemase or P504S), and GST-[alpha], but it may also aberrantly express distal tubule markers, such as BerEP4.
Immunohistochemical study was done for a panel of antibodies including CD5, CD10, CD20, bcl-2 and cyclin D1.
Differential Diagnosis of Acquired Cystic Disease- Associated Renal Cell Carcinoma ACDRCC CCRCC PRCC Morphology Architecture Papillary, Alveolar, Papillary cribriform, acinar, tubulocystic solid Cytology Eosinophilic, Clear Basophilic or foamy eosinophilic Nuclear grade High Moderate-high Low-high Helpful features Calcium Intratumoral Psammoma oxalate, hemorrhage bodies, cytoplasmic foamy microvacuoles macrophages Immunohistochemistry AMACR + -/focal + CD10 + + + CK7 -/focal - + RCC Ma + + + Molecular Chromosomal gains 3, 7, 17 5q 7, 12, 16, 17, 20 Chromosomal losses 3p (VHL gene: Y 3p25.
D 90 CD10 M 024 H16 in Bakalite Hylam (Grade:F1 03)
Upon immunohistochemical examination, these small monotonous lymphoid cells were stained positively with CD20 and Bcl2 and were negative for CD3, CD5, CD10, and CD23.
Positive staining of the follicles using a BCL2 immunohistochemical stain is consistent with follicular lymphoma, but only if the positive cells display GCB differentiation (ie, express CD10 and BCL6).