Neither parts were stained with CD10
, chromogranin A and synaptophysin.
Ninety-two percent of the blasts were CD7 and CD5-positive and CD13, CD33, CD10
, CD19, CD20, CD22, CD14 and HLA-DR-negative.
Immunophenotyping of these tumor cells reveals that they express surface immunoglobulins and B-cell antigens but lack CD5, CD10
, and CD23.
Reactivation of doxorubicin occurs extracellularly in the tumor through enzymatic cleavage of the peptide by at least two enzymes: CD10
(Neprilysin / CALLA) and Thimet Oligopeptidase (TOP).
Since distinguishing SPN from neuroendocrine tumor can be difficult in some cases, using a selected panel of immunostains including b-catenin, CD10
, synaptophysin, and chromogranin is highly recommended for the definite diagnosis.
The tumour was uniformly negative for CD10
, desmin and alpha-smooth muscle actin.
Immunophenotypic characterization has determined the neoplastic cell expresses proximal tubule markers, such as CD10
, RCC marker, [alpha]-methyl-acyl-coenzyme A (AMACR; also known as racemase or P504S), and GST-[alpha], but it may also aberrantly express distal tubule markers, such as BerEP4.
Immunohistochemical study was done for a panel of antibodies including CD5, CD10
, CD20, bcl-2 and cyclin D1.
Differential Diagnosis of Acquired Cystic Disease- Associated Renal Cell Carcinoma ACDRCC CCRCC PRCC Morphology Architecture Papillary, Alveolar, Papillary cribriform, acinar, tubulocystic solid Cytology Eosinophilic, Clear Basophilic or foamy eosinophilic Nuclear grade High Moderate-high Low-high Helpful features Calcium Intratumoral Psammoma oxalate, hemorrhage bodies, cytoplasmic foamy microvacuoles macrophages Immunohistochemistry AMACR + -/focal + CD10
+ + + CK7 -/focal - + RCC Ma + + + Molecular Chromosomal gains 3, 7, 17 5q 7, 12, 16, 17, 20 Chromosomal losses 3p (VHL gene: Y 3p25.
D 90 CD10
M 024 H16 in Bakalite Hylam (Grade:F1 03)
Upon immunohistochemical examination, these small monotonous lymphoid cells were stained positively with CD20 and Bcl2 and were negative for CD3, CD5, CD10
, and CD23.
Positive staining of the follicles using a BCL2 immunohistochemical stain is consistent with follicular lymphoma, but only if the positive cells display GCB differentiation (ie, express CD10