CD10

CD10

a type II transmembrane protein found on pre-B cells, germinal-center B cells, some neutrophils, kidney cells, T-cell precursors, and epithelial cells that acts as a zinc metalloprotease cleaving peptide bonds on the amino side of hydrophobic amino acids; expressed in acute lymphocytic leukemia and follicular-center-cell lymphomas.
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Those lymphoma cells expressed diffuse positive immunohistochemical stain for CD20, CD79a, CD5, and cyclin D1, but were negative for CD10, CD23, BCL6, and MUM1.
The focal endometrial stroma stained strongly positive for CD10. The conclusion was a finding of pleural endometriosis.
Immunohistochemical staining were carried out on the cell block and core biopsy sections using antibodies to thyroid transcriptor factor-1 (TTF-1), Napsin-A, Thyroglobulin, CD10, PAX 8, AMACR, CA19-9 and CD57 (Automated Ventana Bench Mark machine, the EnVisionTm System).
Immunohistochemistry (IHC) showed positive cytokeratin (CK) 18, vimentin, PAX2, PAX8, and focal CD10 staining [Figure 2]b, [Figure 2]c, [Figure 2]d and negative staining for CK 7, CK 20, CD56, synaptophysin, and chromogranin A.
Immunohistochemical staining of CD10, CK 5/6 and p63 revealed that epithelial proliferation was restricted to the basement membrane (Figure 2).
CD10 expression can help in predicting the behavior of these tumors.
Peripheral blood flow cytometric immunophenotyping revealed a 40% population of aberrant B-lymphoblasts, that were CD45 (-), CD10 (+), CD22 (+), CD20 variably (+), CD19 (+), HLA-DR variably (+), CD34 partial (+), CD56 partial (+), Tdt (+), and negative for the remaining lymphoid and myeloid markers tested, including CD14, CD5, CD7, CD33, CD13, CD3, CD4, CD8, CD117, CD16, and MPO (Figure 2).
Bone marrow biopsy showed nodular and interstitial proliferation of small, partially atypical T lymphocytic cells positive for CD2, CD3, CD5, CD8, granzyme and TIA and negative for hairy cell markers, CD10, MUM 1, bcl 1, CD4 and CD56.
In 32% (9/28) AML patients, CD5, CD7, CD64dim, CD10, CD117, CD25 and TdT were expressed while in 25% (7/28) ALL patients CD33, CD13, HLA-DR and CD3 were detected.
Immunohistochemical analysis showed local pan-cytokeratin (+), vimentin (+), P63 (−), cytokeratin 516 (−), CD34 (+), few scattering in the CD68 (+), Ki-67: 50%, the local smooth muscle actin (+), the local S-100 (+), estrogen receptor (−), progesterone receptor (−), E-cadherin (−), dosmin (−), actin (+), the local CD10 (+), and CD117 (−).{Figure 1}