All the tumors (n=63) were positive for CD 117
. DOG 1 was performed in n=19 cases, of which 17 were positive.
(1,4) Another panel of immunohistochemical markers including CD 117
, S-100, CD34, and DOG-1 was performed to exclude other spindle cell neoplasms with GIST as a primary suspect.
, DOG 1, S100, CD34, chromogranin, synaptophysin, CD56, CD57, PGP9.5, and desmin were all negative.
Immunohistochemically, ACC cells stain positively with broad spectrum cytokeratin, CAM 5.2, CK7, CD 117
, and EMA.
In the immunohistology, the tumor was positive for smooth muscle actin (ASMA), bcl-2, CD 99, CD 117
, DOG-1, and some cells also for CD 34 (Figure 2).
Los marcadores inmunohistoquimicos utiles en el diagnostico son: CK7 y CD 117
. Las metastasis a distancia se han reportado aproximadamente en el 48% de los pacientes el orden de frecuencia son: pulmon (67,9%), hueso (10,7%), rinon (10,7%), cerebro (7,1%) e higado (3,6%).
MPO and CD 117
were negative according to flow cytometry.
The spindle cells were negative for melanin A, HMB-45, epithelial membrane antigen, pankeratin, muscle actin, CD 117
, low-molecular-weight keratin, high-molecular-weight keratin, CD34, CD5, factor VIIIa, and CD45/leukocyte common antigen.
CD 34+ fibrocytes, alpha- smooth muscle antigen-positive myofibroblasts, and CD 117
expression in the stroma of invasive squamous cell carcinomas of the oral cavity, pharynx, and larynx.
Immune markers revealed: 56% of the blasts were positive for CD2, CD4, CD33, CD11b, CD11c, CD 15, CD36, CD38, CD56, CD 117
Pathologic examination revealed it to be a gastrointestinal stromal tumor (GIST) that had originated in the stomach and was positive in the antibody study for VIM, CD 34, and CD 117