CD 117

CD 117

Protooncogene that encodes the transmembrane tyrosine kinase receptor CD 117; detected by flow cytometry in most cases of acute myeloid leukemia, in small numbers of T- and B-lymphoblastic lymphomas, and in some gastrointestinal stromal tumors.
Synonym(s): c kit
References in periodicals archive ?
Schwannomas are S100 positive, GIST are CD 117 and DOG1 positive, leiomyoma and leiomyasarcoma shows positivity for Smooth muscle actin and desmin.
Tender notice number : SR C CD 117 1196Providing fully comprehensive Lift ID:2016_PWDM_165982_1
Los marcadores inmunohistoquimicos utiles en el diagnostico son: CK7 y CD 117.
2 Becton - - - - Dickinson CK 5/6 Dako MMAH D5/16 IgG1, M7237 B4 kappa CK 7 Dako MMAH OV-TL IgG1, M7018 12/30 kappa CK 8 Dako MMAH 35PH11 - N1560 CD 10 Dako MMAH 56C6 IgG1 M7308 CD 68 Dako MMAH PG-M1 IgG3, M0876 kappa CD 117 Dako Polyclonal - - A4502 rabbit anti-human
The spindle cells were negative for melanin A, HMB-45, epithelial membrane antigen, pankeratin, muscle actin, CD 117, low-molecular-weight keratin, high-molecular-weight keratin, CD34, CD5, factor VIIIa, and CD45/leukocyte common antigen.
CD 34+ fibrocytes, alpha- smooth muscle antigen-positive myofibroblasts, and CD 117 expression in the stroma of invasive squamous cell carcinomas of the oral cavity, pharynx, and larynx.
Immune markers revealed: 56% of the blasts were positive for CD2, CD4, CD33, CD11b, CD11c, CD 15, CD36, CD38, CD56, CD 117 and HLA-DR.
Pathologic examination revealed it to be a gastrointestinal stromal tumor (GIST) that had originated in the stomach and was positive in the antibody study for VIM, CD 34, and CD 117 (kit protein).
Immunohistologically most GISTs have CD 34 antigen and CD 117 antigen.
On immunohistochemistry examination, the tumor was found to have CD 117 antigen, which is an established hallmark of GIST.
The diagnosis of seminoma was confirmed by further immunohistochemical studies (figure 2, C), although the negative staining for placental alkaline phosphatase and CD 117 are considered to be atypical for seminoma.