CD 117

CD 117

Protooncogene that encodes the transmembrane tyrosine kinase receptor CD 117; detected by flow cytometry in most cases of acute myeloid leukemia, in small numbers of T- and B-lymphoblastic lymphomas, and in some gastrointestinal stromal tumors.
Synonym(s): c kit
References in periodicals archive ?
All the tumors (n=63) were positive for CD 117. DOG 1 was performed in n=19 cases, of which 17 were positive.
(1,4) Another panel of immunohistochemical markers including CD 117, S-100, CD34, and DOG-1 was performed to exclude other spindle cell neoplasms with GIST as a primary suspect.
CD 117, DOG 1, S100, CD34, chromogranin, synaptophysin, CD56, CD57, PGP9.5, and desmin were all negative.
Immunohistochemically, ACC cells stain positively with broad spectrum cytokeratin, CAM 5.2, CK7, CD 117, and EMA.
In the immunohistology, the tumor was positive for smooth muscle actin (ASMA), bcl-2, CD 99, CD 117, DOG-1, and some cells also for CD 34 (Figure 2).
Los marcadores inmunohistoquimicos utiles en el diagnostico son: CK7 y CD 117. Las metastasis a distancia se han reportado aproximadamente en el 48% de los pacientes el orden de frecuencia son: pulmon (67,9%), hueso (10,7%), rinon (10,7%), cerebro (7,1%) e higado (3,6%).
The spindle cells were negative for melanin A, HMB-45, epithelial membrane antigen, pankeratin, muscle actin, CD 117, low-molecular-weight keratin, high-molecular-weight keratin, CD34, CD5, factor VIIIa, and CD45/leukocyte common antigen.
CD 34+ fibrocytes, alpha- smooth muscle antigen-positive myofibroblasts, and CD 117 expression in the stroma of invasive squamous cell carcinomas of the oral cavity, pharynx, and larynx.
Immune markers revealed: 56% of the blasts were positive for CD2, CD4, CD33, CD11b, CD11c, CD 15, CD36, CD38, CD56, CD 117 and HLA-DR.
Pathologic examination revealed it to be a gastrointestinal stromal tumor (GIST) that had originated in the stomach and was positive in the antibody study for VIM, CD 34, and CD 117 (kit protein).