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Related to CCl4: N2O3

carbon tetrachloride (CCl4)

Etymology: L, carbo + Gk, tetra, four, chloros, greenish
a colorless, volatile toxic liquid used as a solvent. CCl4 is particularly toxic to the kidneys and liver; permanent damage to these organs may result from exposure.


A chemokine encoded by CCL4 (formerly LAG1, SCYA4), located on chromosome 17q21-q23, which precipitates local inflammatory response characterised by infiltration of neutrophils. It is expressed after cell activation by mitogens (phytohemagglutinin, bacterial endotoxins or Staphylococcus aureus) and IL2, and inhibited by glucocorticoids, TGF-beta and cyclosporin A.

Normal expression
T-cells, B-cells, monocytes.

Abnormal expression
Various tumour cell lines.


References in periodicals archive ?
Concentrations of CC chemokines CCL2, CCL4, CCL11, CCL13, CCL17, CCL22, and CCL26 in bronchoalveolar lavage fluid
Mouse CCL4, CXCL9, and CXCL10 are lyophilized, available in convenient sizes (5 and 25 micrograms) and in-stock ready to ship.
Otro mecanismo propuesto para la reduccion de la fibrosis ha sido la expresion de metaloproteinasas, necesarias para la degradacion de la matriz, por parte de las celulas mesenquimales trasplantadas a higados con dano hepatico fulminante por CCl4 (40).
Cardioprotective role of leaves extracts of Carissa opaca against CCl4 induced toxicity in rats.
In acute-phase proteins (APPs), A2ML1, CR2, and CCL4 mRNA levels were upregulated in assisted ducklings compared with those in normal ducklings.
with emphasis on their diagnostic use: Study of CCl4 toxicity and a case of Aeromonas infection Journal of Fish Biology, 1975; DOI: 10.
To optimize and improve the reaction conditions, the effect of various agents on the reaction rate and yield, such as solvent (CHCl3, CH2Cl2, CCl4, CH3CN and CH3COOH/ H2O), molar ratio and temperature were investigated.
Acute and subacute liver damage persuaded by CCl4 in rats, this liver injury significantly decreases by giving curcumin [24].
Tenders are invited for Purchase of Laboratory equipments -Lees DISC Apparatus , CCl4 (Carbon tetra chloride,.
TREM-1 cross-linking has been associated with an induced release of inflammatory cytokines such as TNF-[alpha], IL-6, and chemokines such as CXCL8, CCL4, and CCL5.
Because CCl4 cannot be dissolved in water, the CCl4 working solution was prepared with ethanol as the solvent.