CCRL1 | definition of CCRL1 by Medical dictionary
CX3CR1 (redirected from CCRL1)
CX3CR1 A gene on chromosome 3p21.3 that encodes a G protein-coupled receptor for fractalkine, a transmembrane protein and chemokine involved in leukocyte adhesion and migration. CX3CR1 is also a coreceptor for HIV-1; some alternatively spliced forms of CX3CR1 lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS.
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References in periodicals archive
In addition, a chemokine-scavenging molecule, CCRL1
, is expressed by lymphatic ECs that line the ceiling but not the floor of the subcapsular sinus.
Comparative modeling of CCRL1
, a key protein in masked immune diseases and virtual screening for finding inhibitor of this protein.
Furthermore, five atypical chemokine receptors CCRL1
, CCRL2, CXCR7, DARC, and CCBP2, initially known as "silent" or "decoy" receptors, have been identified in recent years.