CX3CR1

(redirected from CCRL1)

CX3CR1

A gene on chromosome 3p21.3 that encodes a G protein-coupled receptor for fractalkine, a transmembrane protein and chemokine involved in leukocyte adhesion and migration. CX3CR1 is also a coreceptor for HIV-1; some alternatively spliced forms of CX3CR1 lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS.
References in periodicals archive ?
In addition, a chemokine-scavenging molecule, CCRL1, is expressed by lymphatic ECs that line the ceiling but not the floor of the subcapsular sinus.
Comparative modeling of CCRL1, a key protein in masked immune diseases and virtual screening for finding inhibitor of this protein.
Furthermore, five atypical chemokine receptors CCRL1, CCRL2, CXCR7, DARC, and CCBP2, initially known as "silent" or "decoy" receptors, have been identified in recent years.