CCR8


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CCR8

A gene on chromosome 3p22 that encodes a member of the beta chemokine receptor family, which is similar to G protein-coupled receptors. CCR8 is preferentially expresses in the thymus; its ligands include thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 (MIP-1) beta. CCR8 is thought to have a central role in regulating monocyte chemotaxis and thymic cell apoptosis, and it may also contribute to positioning of activated T cells within antigenic challenge sites and specialised areas of lymphoid tissues.
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Since qattil type adjectives sometimes perform a function similar to that of Participles, it is useful to include a brief comment about instances of pronoun + qattil adjective (Mk 7:6 [CSROe]; 14:37 [CSRPe]; Jn 13:29 CCR8).
(27) Although the Greek Present Indicative copula is usually translated in CPA with a personal pronoun, there are also at least six attested instances translated with [phrase omitted] + pronoun (Mt 1:20 CCR3; 26:48 CCR1; 27:40 CCR8, CCR1; Lk 11:29 [CSRPc]; 19:9 [CSRPc]; Jn 6:33 [CSRPc]).
There are at least nine instances of [phrase omitted] + pronoun (Mt 23:16 CCR1, [CSROe]; 23:18 CCR1; 28:6 CCR1; Mk 9:40 [CSROc], [CSRPe]; 12:27 [CSRPc]; 16:6 [CSRPc]; Lk 9:50 [CSRPc], [CSRSe]; 18:11 [CSRS/Pc]; Jn 15:19 [T-Sd]) and three instances of [phrase omitted] by itself (Mt 18:14 [CSRPe]; Jn 13:16 CCR8; 15:20 CCR8).
Attested are the expressions [phrase omitted] (Mt 24:5 [CSROe]; 26:25 CCR1; Lk 1:19 [CSROc], [Damb]; Jn 13:19 CCR8; 15:1 [T-Sc]) and [phrase omitted] [phrase omitted] (Mt 26:63 [CSRG/Od]; 27:11 CCR1, [CSROe], [CSRPf]; Mk 15:2 [CSROe]; Lk 7:19 [CSRPg]; 7:20 [CSRPg]).
(2004) Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes.
Luster, "Contribution of CCR4 and CCR8 to antigenspecific TH2 cell trafficking in allergic pulmonary inflammation," Journal of Allergy and Clinical Immunology, vol.123, no.1, e36, pp.67-73, 2009.
As a ligand for CCR4 and CCR8, which are expressed by T cells, it might also be involved in the specific interaction of DCs with T cells.
[4] Human genes: RPLPO, ribosomal protein, large, P0; PPIA, peptidylprolyl isomerase A (cyclophilin A); TNFRSF1A, tumor necrosis factor receptor superfamily, member 1A; CCL11, CCL17, CCL19, CCL22, CCL3, CCL4, chemokine (C-C motif) ligand 11, 17, 19, 22, 3, and 4; CL5 chemokine (C-C motif) ligand 5; CCR1, CCR7, CCR8, chemokine (C-C motif) receptor 1, 7, and 8; CD86, CD86 molecule; CXCL12, chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1); CXCL2, chemokine (C-X-C motif) ligand 2; CXCR4, chemokine (C-X-C motif) receptor 4; L128, interleukin 12B (natural killer cell-stimulating factor 2, cytotoxic lymphocyte maturation factor 2, p40); IL15, IL4, IL8, interleukin 15, 4, and 8; HPRT1, hypoxanthine phosphoribosyltransferase 1; PGK1, phosphoglycerate kinase 1.
Peripheral T-cell lymphoma NOS is distinguished by gains on chromosome 8 (including 8q22-8q24.2 containing MYC) and losses on 9p21 (containing p16/CDKN2A, tumor suppressor gene) (336,340,341); concurrent gene expression analysis showed higher expression of skin-homing chemokine receptors CCR10 and CCR8 on C-ALCL, which potentially explains the lower tendency of C-ALCL to disseminate.
Gel electrophoresis revealed bands corresponding to the expected sizes of CCR1, CCR3, CCR4, CCR8, V28, and CCR11, while there were no bands for CCR2, CCR5, CCR6, or CCR7 (Figure 2).
We also demonstrated that RPE cells express CCR1, CCR3, CCR4, CCR8, and CCR11, while CCR2, CCR5, CCR6, and CCR7 were not expressed by these cells.
PCR products of the predicted sizes for CCR8, V28, and CCR11 (428 bp, 349 bp, and 320 bp, resp.) were amplified from cellular RNA (b).