CCR8


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CCR8

A gene on chromosome 3p22 that encodes a member of the beta chemokine receptor family, which is similar to G protein-coupled receptors. CCR8 is preferentially expresses in the thymus; its ligands include thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 (MIP-1) beta. CCR8 is thought to have a central role in regulating monocyte chemotaxis and thymic cell apoptosis, and it may also contribute to positioning of activated T cells within antigenic challenge sites and specialised areas of lymphoid tissues.
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2004) Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes.
However, Mo-DCs also express CCR8, indicating--like CCR7--its role in DC migration from skin to the lymph node (14).
As a ligand for CCR4 and CCR8, which are expressed by T cells, it might also be involved in the specific interaction of DCs with T cells.
In contrast to ALK+ ALCL, there was also lower expression of cytotoxic molecules, cathepsins, and Th17 cell-associated molecules, and higher expression of some cytokines/receptors (CCL1, CCL22, CCR8, CCR4, IL-13RA2, CXCL14, TGF-bR1) and antiapoptotic molecules (BCL2, BIRC6, BIC), and lower expression of some proapoptotic genes (BAX, BCL2L1, BNPIP3).