CCR7

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CCR7

A gene on chromosome 17q12-q21.2 that encodes a member of the beta chemokine receptor family, which is similar to G protein-coupled receptors. CCR7 is expressed in various lymphoid tissues and activates B and T lymphocytes. It controls migration of memory T cells to inflamed tissues and stimulates dendritic cell maturation.

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In addition, CCR7's function can be modulated locally; CCR7 is upregulated by locally generated molecules including prostaglandin E2 (55) and extracellular [NAD.

59) In the case of lymphocytes, CXCL12 acts in synergy with CCR7 ligands to promote cell migration by sensitizing the cells through CXCR4, thus enabling them to respond to lower concentrations of CCR7 ligands.

The molecular cues regulating immune cell trafficking

And when it comes to CD103 trafficking, CCR7 is like the address on an envelope.

United States : Go-Between Immune Cell is Key to Priming the Bodys Fight Against Cancer

The upregulation of CCR7 upon maturation of DCs was shown in 1998 (12).

Microarray-based in vitro test system for the discrimination of contact allergens and irritants: identification of potential marker genes

Con respecto al fenotipo, la exposicion al VIH-1 induce la expresion de CCR7 tanto en las DCP como en las DCM, lo que puede explicar el incremento de esas DC en los nodulos linfoides durante la infeccion primaria por el VIH-1 (38).

Las celulas dendriticas en la infeccion por el VIH-1

We demonstrated that activation of CCR7 by CCL21 can induce increased cell viability and mammosphere forming ability of colorectal cells via AKT/GSK-3[beta] signals.

CCL21 Facilitates Chemoresistance and Cancer Stem Cell-Like Properties of Colorectal Cancer Cells through AKT/GSK-3[beta]/Snail Signals

2a] K, PE conjugated; BD Biosciences); and chemokine receptors CCR7 (4B12, rat Ig[G.

Effects of diisononyl phthalate on atopic dermatitis in vivo and immunologic responses in vitro

It is now established that activated T cells express more CCR1 through CCR7 (11).

Investigation of apoptotic markers among human immunodeficiency virus (HIV-1) infected individuals

Gene expression changes in foam cells and the role of chemokine receptor CCR7 during atherosclerosis regression in ApoE-deficient mice.

Periadventitial fat: regional source of inflammation in atherosclerosis

low] Marcadores fenotipicos CD16 +++ CD56 - / + Receptores inhibidores KIR +++ NKG2A - / + CD94 - / + ILT-2 + Moleculas de adhesion CD2 + CD62L - / + CD44 + LFA-1 ++ Receptores de citoquinas y quimioquinas Alta afinidad IL-2 - Baja afinidad IL-2 ++ IL-1 - / + CCR7 - CXCR1 +++ CXCR3 - / + CX3CR1 +++ Subgrupo de celulas NK [CD16.

Celulas NK: generalidades y papel durante la infeccion por el virus de la inmunodeficiencia humana tipo 1 (VIH-1)

Expression of FCER2 (32, 33), CD52 (34), FAIM3 (33), CCR7 (30), HLA-DRA (34), and BTG1 (29) has been associated with B-CLL.

Transcriptional profiling of hematologic malignancies with a low-density DNA microarray

In addition, only DCs expressing functional HIF-1[alpha] showed an increase of surface CCR7 after hypoxic differentiation.

Dendritic Cells under Hypoxia: How Oxygen Shortage Affects the Linkage between Innate and Adaptive Immunity