CCR7


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CCR7

A gene on chromosome 17q12-q21.2 that encodes a member of the beta chemokine receptor family, which is similar to G protein-coupled receptors. CCR7 is expressed in various lymphoid tissues and activates B and T lymphocytes. It controls migration of memory T cells to inflamed tissues and stimulates dendritic cell maturation.
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Koets, "[gamma][delta] T cell homing to skin and migration to skin-draining lymph nodes is CCR7 independent," The Journal of Immunology, vol.
The complete CCR7 open reading frame (ORF) was PCR-amplified with primers containing ApaI or NotI restriction sites (57-agggggcccgccaccATGGACCCAGGGAAACCCAGG-37 and 57-ataagaatgcggccgcCTACGGGGAGAAGGTTGTGGTG-37, resp.) and inserted into the pDC316mCMV-EGFP shuttle vector to generate pDC316-mCMVCCR7-EGFP.
And when it comes to CD103 trafficking, CCR7 is like the address on an envelope.
Tfh and Th17 cells also differ in the ability to home to different immune microenvironments; while most Tfh cells are [CXCR5.sup.+] and migrate to the secondary lymphoid tissue B cell areas, Th17 cells, when activated, down regulate CCR7 and up regulate CCR6, migrating to the target organs where they exert their effector functions.
CCL21, CCL19, and its receptor CCR7 take part in a series of immunological processes including T cell homeostasis [32], the generation of thy-mocytes [33, 34], regulatory T cell (Treg) function [35-37], and central and peripheral tolerance [38, 39].
However, trogocytosis is characterized by relatively short gene transfer times (72 hours for CCR7 and 2h for CD19) and has so far relied on liver donor cells to reach high expression levels (from 50% to 80% for CCR7 and 19% to 47% for CD19).
We also demonstrated that RPE cells express CCR1, CCR3, CCR4, CCR8, and CCR11, while CCR2, CCR5, CCR6, and CCR7 were not expressed by these cells.
These genes include Ets-1 and FoxP3 [32]; ITGAM and FcyRIIIA [33]; PD-1.3A, C4AQ0, and MBL [34]; AlFadhli (IRF9, ABCA1, APOBEC3, CEACAM3, OSCAR, TNFA1P6, MMP9, and SLC4A1) [35]; FCGR3A and FCGR3B [36]; Tlr7 [37]; TBX21 and IFNG [38]; CD95 and CCR7 [39]; Fkbp11 [40]; JHDM1D and HDAC1-3 [41]; IL-28RA [42]; andpSTAT1 and ETS1 [43].
The CCR7 Ligand Is Necessary for the Induction of Pathogenic Th17 Cells.
have suggested that the dendritic cells (DCs) in the decidua are immobile despite being responsive to the chemokine CCL21, one of the ligands for CCR7 that enable homing to lymphatics.
CCR7 which is expressed by activated T cells [66] as well as innate lymphoid type 3 cells (ILC3) [66, 67] binds both CCL19 and CCL21.
Based on CCR7 and CD45RA expression, we found that [CD4.sup.+] and [CD8.sup.+] T cells from both compartments were dominated by an effector memory T cell phenotype at the expense of naive cells (Figure 4(a)).