, a CC chemokine receptor that interacts with macrophage inflammatory protein 3a and is highly expressed in human dendritic cells.
The roles of CCR6
in migration of Th17 cells and regulation of effector T-cell balance in the gut.
(2010) A regulatory variant in CCR6
is associated with rheumatoid arthritis susceptibility.
Nishimura et al., "Identification of CCR6
, the specific receptor for a novel lymphocyte-directed CC chemokine LARC," The Journal of Biological Chemistry, vol.
Expression of CCR6
and CD83 by cytokine-activated human neutrophils.
TI-Treg cells express a variety of chemokine receptors, including CCR4, CCR5, CCR6
, CCR7, CCR10, CXCR3, and CXCR4, and migrate efficiently in response to tumor-derived chemokines [23, 95, 96].
Analysis of the expression levels of the chemokine receptors CXCR3, CCR6
, and CCR4 enables further characterization of peripheral blood Thelper-like subsets [35-37].
The majority of the extracellular flow cytometry experiments were performed directly on fresh cells, but for six donors, the T cell markers CD69, CD25, CXCR3, CCR6
, CD38, HLA-DR, CD127, and PD-1 were analyzed on paired frozen samples.
Tfh and Th17 cells also differ in the ability to home to different immune microenvironments; while most Tfh cells are [CXCR5.sup.+] and migrate to the secondary lymphoid tissue B cell areas, Th17 cells, when activated, down regulate CCR7 and up regulate CCR6
, migrating to the target organs where they exert their effector functions.
(47),(68),(69) The interaction between chemokines produced in the interfollicullar region of the PPs and chemokine receptors, such as between CCL19 and CCR7 and between CCL20 and CCR6
, plays an important role in the transport of dendritic cells to T cell zones.
Thus, these chemokine receptors, along with CCR6
, are involved in recruiting Tregs to the tumor site.
Furthermore, Langerhans cell recruitment is induced by CCR6
related chemokines .