CCR5


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CCR5

A gene on chromosome 3p21.31 that encodes a member of the beta chemokine receptor family, which is similar to G protein-coupled receptors. CCR5 is expressed by T cells and macrophages; it is a receptor for various CC-chemokines, including MIP-1-alpha, MIP-1-beta and RANTES, and transduces a signal by increasing the intracellular calcium ion level. CCR5 may play a role in the control of granulocytic lineage proliferation or differentiation, and is an important co-receptor for macrophage-tropic viruses (e.g., HIV-1) entering host cells.

CCR5

A chemokine receptor; defects in its structure caused by genetic mutation cause the progression of AIDS to be prevented or slowed.
Mentioned in: AIDS
References in periodicals archive ?
In the setting of cancer, research has shown that CCR5 plays an important role in tumor invasion and metastasis.
"If we are going to talk about remission and getting people off of ART (antiretroviral treatment) for life, then targeting CCR5 therapeutically is an option that we need to explore further," University of Cambridge professor and lead author of the Nature study, Ravindra Gupta, told AFP.
Its effectiveness underlines the importance of developing new strategies based on preventing CCR5 expression," said co-author Dr Ian Gabriel (Imperial College Healthcare NHS Trust).
"We need to understand if we could knock out this (CCR5) receptor in people with HIV, which may be possible with gene therapy," he said.
One possibility, said Deeks and others, is to develop gene-therapy approaches to knock out CCR5 on immune cells or their predecessor stem cells.
Il a subi en 2016 une transplantation a base de cellules souche hematopoietiques d'un donneur porteur d'une mutation du gene du CCR5 qui n'est presente que chez 1% de la population mondiale.
"Prof Ravindra Gupta from University College London and lead author of the paper on the successful treatment of the London patient, published in the journal Nature, said the way forward could be the editing of the CCR5 gene, which allows HIV to enter cells."A field was generated as a result of the Berlin patient looking at CCR5 gene-editing," he said.
"The patient received the stem cell transplant from a donor with a rare CCR5 mutation that allows HIV resistance.
Previous studies on this subject have had conflicting results of the effect of Tax-1 on CCR5 expression (11,12).
Jiankui claims to have used CRISPR and Cas9 to turn off expression of the CCR5, a protein that plays a part in our immune system.
Pestell's research which showed three key properties of the CCR5's Mechanism of Action.
Pestell and others that CCR5 is a key target for metastasis in many types of cancer.