In the setting of cancer, research has shown that CCR5
plays an important role in tumor invasion and metastasis.
"If we are going to talk about remission and getting people off of ART (antiretroviral treatment) for life, then targeting CCR5
therapeutically is an option that we need to explore further," University of Cambridge professor and lead author of the Nature study, Ravindra Gupta, told AFP.
Its effectiveness underlines the importance of developing new strategies based on preventing CCR5
expression," said co-author Dr Ian Gabriel (Imperial College Healthcare NHS Trust).
"We need to understand if we could knock out this (CCR5
) receptor in people with HIV, which may be possible with gene therapy," he said.
One possibility, said Deeks and others, is to develop gene-therapy approaches to knock out CCR5
on immune cells or their predecessor stem cells.
Il a subi en 2016 une transplantation a base de cellules souche hematopoietiques d'un donneur porteur d'une mutation du gene du CCR5
qui n'est presente que chez 1% de la population mondiale.
"Prof Ravindra Gupta from University College London and lead author of the paper on the successful treatment of the London patient, published in the journal Nature, said the way forward could be the editing of the CCR5
gene, which allows HIV to enter cells."A field was generated as a result of the Berlin patient looking at CCR5
gene-editing," he said.
"The patient received the stem cell transplant from a donor with a rare CCR5
mutation that allows HIV resistance.
Previous studies on this subject have had conflicting results of the effect of Tax-1 on CCR5
Jiankui claims to have used CRISPR and Cas9 to turn off expression of the CCR5
, a protein that plays a part in our immune system.
Pestell's research which showed three key properties of the CCR5
's Mechanism of Action.
Pestell and others that CCR5
is a key target for metastasis in many types of cancer.