Case of yellow fever vaccine-associated viscerotropic disease with prolonged viremia, robust adaptive immune responses, and polymorphisms in CCR5
and RANTES genes.
In an unusual twist, more than a dozen years ago AIDS researchers discovered that CCR5
is the primary coreceptor used by HIV to infect cells.
Since inflammation plays a major role in the pathogenesis of cancers and CCR5
plays an important role in inflammation, the aim of this study was to investigate the association of human papillomavirus (HPV) infection and cancer progression to chemokine receptor 5 (CCR5
In the area of HIV infection, the company is developing the viral-entry inhibitor PRO 140, a humanized monoclonal antibody targeting the HIV entry co-receptor CCR5
, which has completed phase 1b clinical studies with positive results.
Such drugs target the HIV receptor CCR5
, which the virus uses to enter and infect host cells, and has historically only been associated with expression in inflammatory cells in the immune system.
Your doctor can order a test called Trofile to see whether you have virus that uses CCR5
, CXCR4 or both.
We expect that CCR5
antagonists, like maraviroc, will become
A study was published in 1996 that described resistance to HIV-1 infection in certain Caucasian subjects, and in the same year, another journal reported the binding of HIV to the CCR5
In people with the mutation, lacking the CCR5
protein may lead to "a brain infection from West Nile that is not well controlled," Murphy says.
Two risks with this treatment approach are that the CCR5
may turn out to be necessary for some people for unknown reasons--or that when HIV is prevented from using CCR5
, it might evolve within an individual patient to use CXCR4 instead.
We molecularly cloned and expressed the WEAU HIV-1 envelope (env) gene in pTZ19U and determined its tropism from CXCR4 and CCR5
HIV-1, the virus that causes AIDS, uses the chemokine receptors CCR5
and CCR2 as coreceptors with CD4 for entry into lymphoid cells.