CCR5


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CCR5

A gene on chromosome 3p21.31 that encodes a member of the beta chemokine receptor family, which is similar to G protein-coupled receptors. CCR5 is expressed by T cells and macrophages; it is a receptor for various CC-chemokines, including MIP-1-alpha, MIP-1-beta and RANTES, and transduces a signal by increasing the intracellular calcium ion level. CCR5 may play a role in the control of granulocytic lineage proliferation or differentiation, and is an important co-receptor for macrophage-tropic viruses (e.g., HIV-1) entering host cells.

CCR5

A chemokine receptor; defects in its structure caused by genetic mutation cause the progression of AIDS to be prevented or slowed.
Mentioned in: AIDS
References in periodicals archive ?
Table 1--Occurrence of genotypes, genotype frequency and allele frequency of the CCR5 gene in Roraima, Brazil.
An unpaired f-test was used to compare CCR5 expression in samples treated with LPS in the presence of signalling inhibitors with that in samples treated with LPS only.
3] among them one patient was CCR5 negative and showed CD4 count 250 with viral load of 1700.
We also wanted to fill the gaps for polymorphism CCR5 (decreased susceptibility to HIV infection among subjects with [DELTA]32 allele) because Bosnia and Herzegovina is a country progressively opening to tourism.
Mutation risks other than CCR5 delta 32 is not yet confirmed at this time as the research continues to develop.
2-36 billion cells) of his/her own CD4+ T cells, which had been genetically engineered using an adenoviral vector designed to carry a ZFN, an enzyme targeted at permanently disabling CCR5.
Scientists therefore have sought to develop anti-HIV drugs that block the virus from binding to CCR5 or otherwise render the receptor inactive.
Incorporating the three resistant genes helped shield the cells from HIV entry via both the CCR5 and CXCR4 receptors.
The scientists discovered that one of the toxins the bacterium releases, called LukED, latches on to CCR5 and subsequently punches holes through the membrane of immune cells, causing them to rapidly die.
For the siRNA against CCR5, we plan to initiate trials within six months using autologous, gene-modified stem cells," he added.
The ZFNs latched onto the cells' genomes and removed the coding for CCR5.