CCR4


Also found in: Acronyms.

CCR4

A gene on chromosome 3p24 that encodes a G protein-coupled receptor for C-C-type chemokines (MIP-1, RANTES, TARC and MCP-1). CCR4 is a high-affinity receptor for the C-C-type chemokines CCL17/TARC and CCL22/MDC; its activity is mediated by Gi proteins, which activate phosphatidylinositol-calcium second messengers.
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References in periodicals archive ?
Luster, "Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4," Journal of Experimental Medicine, vol.
To investigate whether TJ-20 treatment influences the balance of Th1/Th2 cells in the synovia in AA rats, we examined the percentages of IFN-[gamma]-positive (one of the Th1 cytokines, Figure 4(a)) and IL-4-positive (one of the Th2 cytokines, Figure 4(a)) mononuclear cells and also the percentages of CXCR3 (a marker for Th1 cells)/W3/25-double and CCR4 (a marker for Th2 cells)/W3/25-double positive cells in the synovia of the ankle joints (data not shown).
The report provides comprehensive information on the C-C Chemokine Receptor Type 4 (C-C CKR-4 or K5-5 or CD194 or CCR4), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
Lalor et al., "Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver," The Journal of Immunology, vol.
(10) Nonetheless, in our study recombinant UL128 could enhance the production of CCR1 as well as CCR3 and CCR4 at low concentration (10 ng/mL) which may correlate with its chemotactic function such as recruiting PMBC to the infectious site.
C-C chemokine receptor type 4 (CCR4) protein is a G-protein coupled receptor that acts as the receptor for CCL22.
Other chemoattractant receptors are also preferentially expressed on Th2 cells, including CCR4, CCR8, and CXCR4.
(5,23) Studies have shown that lymphoma cells show variable expression of regulatory Tcell phenotype characterized by [CD4.sup.+]/[CD25.sup.+] (83%; Figure 3); FOXP3+ (36%); CCR4 (95%); and CCR8 (35%).
Izaurralde, "mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes," Genes and Development, vol.
In that context, CXC chemokine receptor 3 (CXCR3) is selectively expressed on memory Th1 cells, while CC chemokine receptor 4 (CCR4) is expressed on memory Th2 cells [8, 9].
Besides being a chemoattractant, CCL11 may also induce eosinophil degranulation [36] and IgE-independent degranulation of basophils [37], promoting adaptive immune responses, through the selective recruitment of Th2 lymphocytes, which is dependent on the expression of CCR4 and CCR8 on Th2 cells [38].