CCR2

(redirected from CCR2B)

CCR2

A gene on chromosome 3p21.31 that encodes a receptor for monocyte chemoattractant protein-1 (MCP-1), a chemokine that mediates monocyte chemotaxis through agonist-dependent calcium mobilisation and inhibition of adenylyl cyclase. MCP-1 plays a role in monocyte infiltration in inflammatory responses to rheumatoid arthritis and tumours.
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References in periodicals archive ?
Induction of chemokines and chemokine receptors CCR2b and CCR4 in authentic human osteoclasts differentiated with RANKL and osteoclast like cells differentiated by MCP-1 and RANTES.
In CCR2 polymorphism at position 190 from G to A, a mutation called CCR2-V64I causes a change from valine to isoleucine at codon 64, and it has been shown that this change causes a higher expression of CCR2A compared to CCR2B, which in turn downregulates the cell surface expression of CCR5 [33].
Bear et al., "Enhanced tumor trafficking of GD2 chimeric antigen receptor T cells by expression of the chemokine receptor CCR2b," Journal of immunotherapy, vol.
To this end, we designed RT-qPCR probes (Supplementary Table 2) against the two isoforms of CCR2 (CCR2A and CCR2B).
Surprisingly, we did not detect the two cognate CCL2 receptors generated by alternative splicing, namely, CCR2A and CCR2B, in human OE-MSCs from three different donors.
Morrison, "Induction of chemokines and chemokine receptors CCR2b and CCR4 in authentic human osteoclasts differentiated with RANKL and osteoclast like cells differentiated by MCP-1 and RANTES," Journal of Cellular Biochemistry, vol.
This change makes the CCR2A isoform more stable and increases its half-life but does not affect the stability of the isoform CCR2B [1, 40].
[6] While most HIV-1 variants use CCR5 and CXCR4 as the main co-receptor in vivo, up to 12 other chemokine co-receptors (including CCR2b, CXCR6 and GPR1) for HIV infection have been identified in vitro.
HIV-1 and HIV-2 strains have been reported to be capable of utilising several alternative chemokine receptors, including CCR2b, CXCR4, CXCR6 and GPR1, to mediate infection of cells.
The epithelial surface expresses all the receptors necessary for HIV infection including CD4, CCR5, CXCR4 [64, 65], and various other G protein-coupled coreceptors (GPCRs) known to mediate entry of HIV into cells (including CCR2b, CXCR6, and GPR1) [63, 66], indicating a vast area of the female genital tract that can potentially be infected.
Furthermore as highlighted earlier, the epithelial surface expresses all the receptors necessary for HIV infection including CD4, CCR5, CXCR4 [64, 65], and various other G protein-coupled coreceptors (GPCRs) known to mediate entry of HIV into cells (including CCR2b, CXCR6, and GPR1) [63, 66].
Wang, "Monocyte chemotactic protein2 (MCP-2) uses CCR1 and CCR2B as its functional receptors," Journal of Biological Chemistry, vol.