CCR10

CCR10

A gene on chromosome 17q21.1-q21.3 that encodes a member of the chemokine receptor family, which is similar to G protein-coupled receptors. CCR10 is the receptor for CCL27, the binding of which results in T cell-mediated skin inflammation.
Mentioned in ?
References in periodicals archive ?
In addition, cytokine-cytokine receptor interaction signaling pathways were predicted to have strong relationships with the target genes, such as CCL23 ( ENST00000591423 ) , CCR10 ( NM_016602 ), and TNFRSF6B (NM_003823) .
CCR10 and its ligands in regulation of epithelial immunity and diseases.
2001) CC chemokine receptor (CCR)4 and the CCR10 ligand cutaneous T cell-attracting chemokine (CTACK) in lymphocyte trafficking to inflamed skin.
Autocrine regulation of re-epithelialization after wounding by chemokine receptors CCR1, CCR10, CXCR1, CXCR2, and CXCR3.
3] or an analogue (nM range) increased the expression of the skin-tropic chemokine receptor CCR10 on cultured T cells [14, 23].
Staining of surface (CD3, CD4, CD25, CCR4, CCR10, neuropilin, MHC class II, and CD11c) and intracellular (Foxp3) antigens was performed as previously described [9].
3] Did Not Affect the Expression of CCR4 or CCR10 on Cells in the SDLN or ADLN.
Entre los mecanismos que controlan la migracion y el posicionamiento de las celulas T en la piel estan las quimiocinas producidas por los queratinocitos, tales como CCL7, CCL27 y CCL4, y la expresion de receptores para las mismas como CCR4, CXCR4, CCR10 y el antigeno leucocitario cutaneo (CLA) (6,7,29).
This translocation creates NPM-ALK (Nucleophosphmin anaplastic lymphoma kinase) gene with transforming potential,7 while other mutations are also implicated like defective expression of TCR, CCR8, and CCR10.
2 containing MYC) and losses on 9p21 (containing p16/CDKN2A, tumor suppressor gene) (336,340,341); concurrent gene expression analysis showed higher expression of skin-homing chemokine receptors CCR10 and CCR8 on C-ALCL, which potentially explains the lower tendency of C-ALCL to disseminate.
CC chemokine receptor [CCR]9, CCR10, [alpha]4[beta]7 integrin) on antigen-specific lymphocytes through the retinoic acid cascade for their subsequent migration to the effector tissues (e.
Estas celulas activadas expresan un fenotipo CD2+, LFA-1, CLA+ y CCR10, que facilita su interaccion con moleculas de adhesion del endotelio como son, selectina P, selectina E y CCL27, que permiten su migracion y acumulacion en la placa psoriatica.