CCR3A gene on chromosome 3p21.3 that encodes a G protein-coupled receptor for C-C-type chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13) and RANTES (CCL5). It is highly expressed in eosinophils and basophils, as well as in TH1 cells, TH2 cells and airway epithelial cells; it may contribute to the accumulation and activation of eosinophils and other inflammatory cells in airways allergies, and is also an entry co-receptor for HIV-1.
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CCR-3CMKBR3, CC CKR3, eotaxin R Cell biology A 41 kD coreceptor for HIV encoded on chromosome 3q21.3 Ligands Eotaxin, Eot-2, Eot-3, MCP-2, MCP-3, MCP-4, MCP-4, MIP-1δ, RANTES. See Coreceptor, RANTES.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.