CCNU


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Related to CCNU: BCNU, lomustine, CCSU

lomustine

 [lo-mus´tēn]
a nitrosourea alkylating agent used as an antineoplastic agent in treatment of Hodgkin's disease and brain tumors, administered orally. Called also CCNU.

lo·mus·tine

(lō-mŭs'tēn),
An antineoplastic agent.
Synonym(s): CCNU

ABDIC

A "salvage" chemotherapy regimen used for patients who have a disease—e.g., lymphoma—relapse after radiation therapy or chemotherapy.

CCNU

Cyclonexyl-chloroethyl-nitrosourea, lomustine Oncology A chemotherapeutic used in adjuvant therapy of high-grade astrocytomas, also used in NHL, melanoma, myeloma, GI CAs Adverse effects N&V, ↓ platelets, ↓ WBCs, 2º leukemia, pulmonary fibrosis, renal failure. See BCNU, Nitrogen mustards.
References in periodicals archive ?
Sometimes, surprisingly to some, it was metabolic and structure-activity evidence (for benzidine-related dyes and CCNU).
The work was supported by the Self-Determined Research Funds of CCNU from the Colleges' Basic Research and Operation of the Ministry of Education (CCNU16A06014, CCNU16JCZX11, CCNU15A02056), the Open Project Program of Key Laboratory of Adolescent Cyberpsychology and Behavior (CCNU), Ministry of Education (2014B06), the Major Program of the National Social Science Foundation of China (11&ZD151), and the National Natural Science Foundation of China (31471000).
Promotor of MGMT encoding [O.sub.6]-methylguanine-DNA methyltransferase is a DNA repair enzyme which can effectively protect cells against alkylating agents (e.g., TMZ and CCNU) through preventing G:C[right arrow]A:T gene mutations [83].
On the 22nd and 23rd July 2015, a Sino-British Conference on Ethical Literary Criticism--"Ethical Power in Chinese and English Romantic Poetry"--was jointly held in Preston and Grasmere, UK, by the Editorial Department for Foreign Literature Studies of Central China Normal University (CCNU, China), and the Confucius Institute of the University of Central Lancashire (UCLan CI, UK).
Initial studies suggested that astrocytomas show poor response to chemotherapy regimens, whereas oligodendrogliomas are sensitive to PCV chemotherapy that consists of procarbazine, lomustine (CCNU), and vincristine.
The most commonly used chemotherapy drugs have been alkylating agents, such as procarbazine (Matulane), temozolomide (Temodar), and the nitrosureas, carmustine (BCNU) and lomustine (CCNU).
Note: Funding for the research of "McCarthy's The Road and Ethical Choice in a Post-Apocalyptic World" has been provided by the National Social Science Fund of China (13&ZD128) and Central China Normal University (CCNU 14Z02005).