CCND2

CCND2

A gene on chromosome 12p13 that encodes a member of the highly conserved cyclin family, which regulates CDK kinases. Cyclin D2 forms a complex with and is a regulatory subunit of CDK4 or CDK6, which are required for cell cycle G1/S transition; it is thought to play a central role in germ cell proliferation. Cyclin D2 interacts with tumour suppressor protein Rb and is involved in its phosphorylation.

Molecular pathology
CCND2 is overexpressed in ovarian and testicular tumours.
References in periodicals archive ?
DADR, BCAT1, and EKI reduce apoptotic susceptibility (176); STELLAR, GDF3, and EDR1 maintain pluripotency of cells, and CCND2 and KRAS provide cells with a proliferative advantage, among other genes on chromosome arm 12p that confer a survival benefit to cells.
The researchers identified several mutations that may contribute as cooperating mutations, including changes in CCND2, a gene that makes a protein involved in the cell cycle.
CCND2 - a gene involved in cell-cycle control, which is a key control mechanism to prevent cancer development
2002 cycle progression at G1 10 CCND2 Essential for the Clappier et al.
III] specific E-cadherin CDH1 Cell-cell adhesion CDC2-related protein CRK7 Protein kinase activity kinase 7 Tubulin-specific TBCD Beta-tubulin folding chaperone d Cisplatin resistance CRR9 Integral to membrane related protein CRR9p Cyclin D2 CCND2 Regulation of cell cycle Polymerase IDNA directed), POLB DNA replication beta Ring finger protein 141 RNF141 Ubiquitin ligase complex Nuclear factor of NFATC2 Transcription factor activated T-cells, activity cytoplasmic, calcineurin-dependent 2 S100 calcium binding S100P Calcium ion binding protein P Fem-1 homolog c FEM1C Unknown (C.
The genes most predictive of overall survival in DLBCL were LMO2, BCL6, FN1, CCND2, SCYA3 and BCL2.
CCND2 rearrangements are the most frequent genetic events in cyclin D1 mantle cell lymphoma.
Subsequent work revealed that let-7 regulates a number of other oncogenes, including CCND2 (cyclin D2), CDK6 (cyclin-dependent kinase 6), CDC25 [cell division cycle 25 homolog C (S.
For example, one risk variant is located near CCND2, the gene encoding cyclin D2, a member of the cyclin family of proteins that regulate the cell cycle.